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Les effets délétères du tabac sur le cerveau...

Une publication de Bernard Mazoyer et du groupe d'imagerie neurofonctionnelle (GIN)

Le 26 novembre 2014

Sex-related and tissue-specific effects of tobacco smoking on brain atrophy: assessment in a large longitudinal cohort of healthy elderly .
Quentin Duriez, Fabrice Crivello and Bernard Mazoyer. Front Aging Neurosci. 2014 Nov 3;6:299. doi: 10.3389/fnagi.2014.00299. eCollection 2014.
University of Bordeaux, Neurofunctional Imaging Group (GIN) UMR5296, Bordeaux, France.
Bordeaux Neurocampus


The  same page and  video in english...

Les résultats de cette étude  battent en brèche l'idée préconçue que le tabac protège du vieillissement car c'est un psychostimulant. Notre étude montre qu'il n'en est rien et qu'au
contraire le tabac est un facteur majeur d'atrophie du cerveau.

 

Abstract PubMed

We investigated the cross-sectional and longitudinal effects of tobacco smoking on brain atrophy in a large cohort of healthy elderly participants (65-80 years). MRI was used for measuring whole brain (WB), gray matter (GM), white matter (WM), and hippocampus (HIP) volumes at study entry time (baseline, N = 1451), and the annualized rates of variation of these volumes using a 4-year follow-up MRI in a subpart of the cohort (N = 1111).

Effects of smoking status (never, former, or current smoker) at study entry and of lifetime tobacco consumption on these brain phenotypes were studied using sex-stratified AN(C)OVAs, including other health parameters as covariates. At baseline, male current smokers had lower GM, while female current smokers had lower WM. In addition, female former smokers exhibited reduced baseline HIP, the reduction being correlated with lifetime tobacco consumption. Longitudinal analyses demonstrated that current smokers, whether men or women, had larger annualized rates of HIP atrophy, as compared to either non or former smokers, independent of their lifetime consumption of tobacco.

There was no effect of smoking on the annualized rate of WM loss. In all cases, measured sizes of these tobacco-smoking effects were of the same order of magnitude than those of age, and larger than effect sizes of any other covariate. These results demonstrate that tobacco smoking is a major factor of brain aging, with sex- and tissue specific effects, notably on the HIP annualized rate of atrophy after the age of 65. 

Bernard Mazoyer, directeur du GIN, université de Bordeaux (bernard.mazoyer @ u-bordeaux.fr)
Dernière mise à jour le 10.12.2014

Bernard Mazoyer et le GIN

Professeur de radiologie et d’imagerie médicale à la Faculté de Médecine de l’Université de Bordeaux, en charge de la neuro-imagerie fonctionnelle dans l’unité de neuroradiologie diagnostique et interventionnelle. Plus...

Le GIN contribue en tant qu’Unité Mixte de Recherche (UMR 5296) à la création du Laboratoire d’Excellence Trail (Translational and Advanced Imaging LabEx) avec un programme de 5 ans financé par le CNRS, le CEA et l’Université de Bordeaux. Plus...