Aller au contenuAller au menuAller à la recherche

Séminaire impromptu - Sudha SeshadriAlzheimer’s Disease: Seeking Genetic Clues to Prevention and Cure"

Abstract :


Sudha Seshadri is a Professor of Neurology at the Boston University School of Medicine, a board-certified neurologist and a Senior Investigator at the Framingham Heart Study. She serves on NIH Study sections, the Editorial Board of Stroke, Neurology, and Journal of Alzheimer Disease, and mentors and teaches medical students, neurology residents, stroke and neuroepidemiology fellows and junior faculty on training grants. She has been leading the neurology working group of the Cohorts of Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium for many years and is a key member of several other international genetic research consortia (IGAP, ISGC, METASTROKE). Pr. Seshadri has played a major role in many recent discoveries of genetic risk variants underlying complex age-related disorders, especially dementia and stroke, as well as MRI-markers of brain aging. She is also a Principal Investigator on the ongoing Alzheimer Disease Sequencing Project jointly funded by the NIA and the NHGRI.

Selected publications

Williams SR,, Seshadri S, Sale MM et al. ; Genomics and Randomized
Trials Network; Framingham Heart Study. Genome-wide meta-analysis of homocysteine
and methionine metabolism identifies five one carbon metabolism loci and a novel
association of ALDH1L1 with ischemic stroke. PLoS Genet. 2014 Mar
20;10(3):e1004214. doi: 10.1371/journal.pgen.1004214. eCollection 2014 Mar.
PubMed PMID: 24651765; PubMed Central PMCID: PMC3961178.


Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C,
DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA,
Jones N, Smith AV, Chouraki V, Thomas C, Ikram MA, Zelenika D, Vardarajan BN,
Kamatani Y, Lin CF, Gerrish A, Schmidt H, Kunkle B, Dunstan ML, Ruiz A, Bihoreau
MT, Choi SH, Reitz C, Pasquier F, Cruchaga C, Craig D, Amin N, Berr C, Lopez OL,
De Jager PL, Deramecourt V, Johnston JA, Evans D, Lovestone S, Letenneur L, Morón
FJ, Rubinsztein DC, Eiriksdottir G, Sleegers K, Goate AM, Fiévet N, Huentelman
MW, Gill M, Brown K, Kamboh MI, Keller L, Barberger-Gateau P, McGuiness B, Larson
EB, Green R, Myers AJ, Dufouil C, Todd S, Wallon D, Love S, Rogaeva E, Gallacher
J, St George-Hyslop P, Clarimon J, Lleo A, Bayer A, Tsuang DW, Yu L, Tsolaki M,
Bossù P, Spalletta G, Proitsi P, Collinge J, Sorbi S, Sanchez-Garcia F, Fox NC,
Hardy J, Deniz Naranjo MC, Bosco P, Clarke R, Brayne C, Galimberti D, Mancuso M,
Matthews F; European Alzheimer's Disease Initiative (EADI); Genetic and
Environmental Risk in Alzheimer's Disease; Alzheimer's Disease Genetic
Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology, Moebus
S, Mecocci P, Del Zompo M, Maier W, Hampel H, Pilotto A, Bullido M, Panza F,
Caffarra P, Nacmias B, Gilbert JR, Mayhaus M, Lannefelt L, Hakonarson H, Pichler
S, Carrasquillo MM, Ingelsson M, Beekly D, Alvarez V, Zou F, Valladares O,
Younkin SG, Coto E, Hamilton-Nelson KL, Gu W, Razquin C, Pastor P, Mateo I, Owen
MJ, Faber KM, Jonsson PV, Combarros O, O'Donovan MC, Cantwell LB, Soininen H,
Blacker D, Mead S, Mosley TH Jr, Bennett DA, Harris TB, Fratiglioni L, Holmes C,
de Bruijn RF, Passmore P, Montine TJ, Bettens K, Rotter JI, Brice A, Morgan K,
Foroud TM, Kukull WA, Hannequin D, Powell JF, Nalls MA, Ritchie K, Lunetta KL,
Kauwe JS, Boerwinkle E, Riemenschneider M, Boada M, Hiltuenen M, Martin ER,
Schmidt R, Rujescu D, Wang LS, Dartigues JF, Mayeux R, Tzourio C, Hofman A,
Nöthen MM, Graff C, Psaty BM, Jones L, Haines JL, Holmans PA, Lathrop M,
Pericak-Vance MA, Launer LJ, Farrer LA, van Duijn CM, Van Broeckhoven C, Moskvina
V, Seshadri S, Williams J, Schellenberg GD, Amouyel P. Meta-analysis of 74,046
individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat
Genet. 2013 Dec;45(12):1452-8. doi: 10.1038/ng.2802. Epub 2013 Oct 27. PubMed
PMID: 24162737; PubMed Central PMCID: PMC3896259.


Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis
JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca
R, Debette S, Longstreth WT Jr, Janssens AC, Pankratz VS, Dartigues JF,
Hollingworth P, Aspelund T, Hernandez I, Beiser A, Kuller LH, Koudstaal PJ,
Dickson DW, Tzourio C, Abraham R, Antunez C, Du Y, Rotter JI, Aulchenko YS,
Harris TB, Petersen RC, Berr C, Owen MJ, Lopez-Arrieta J, Varadarajan BN, Becker
JT, Rivadeneira F, Nalls MA, Graff-Radford NR, Campion D, Auerbach S, Rice K,
Hofman A, Jonsson PV, Schmidt H, Lathrop M, Mosley TH, Au R, Psaty BM,
Uitterlinden AG, Farrer LA, Lumley T, Ruiz A, Williams J, Amouyel P, Younkin SG,
Wolf PA, Launer LJ, Lopez OL, van Duijn CM, Breteler MM; CHARGE Consortium;
GERAD1 Consortium; EADI1 Consortium. Genome-wide analysis of genetic loci
associated with Alzheimer disease. JAMA. 2010 May 12;303(18):1832-40. doi:
10.1001/jama.2010.574. PubMed PMID: 20460622; PubMed Central PMCID: PMC2989531.
4: Maillard P, Seshadri S, Beiser A, Himali JJ, Au R, Fletcher E, Carmichael O,
Wolf PA, DeCarli C. Effects of systolic blood pressure on white-matter integrity
in young adults in the Framingham Heart Study: a cross-sectional study. Lancet
Neurol. 2012 Dec;11(12):1039-47. doi: 10.1016/S1474-4422(12)70241-7. Epub 2012
Nov 2. PubMed PMID: 23122892; PubMed Central PMCID: PMC3510663.

Bis JC, DeCarli C, Smith AV, van der Lijn F, Crivello F, Fornage M, Debette S,
Shulman JM, Schmidt H, Srikanth V, Schuur M, Yu L, Choi SH, Sigurdsson S,
Verhaaren BF, DeStefano AL, Lambert JC, Jack CR Jr, Struchalin M, Stankovich J,
Ibrahim-Verbaas CA, Fleischman D, Zijdenbos A, den Heijer T, Mazoyer B, Coker LH,
Enzinger C, Danoy P, Amin N, Arfanakis K, van Buchem MA, de Bruijn RF, Beiser A,
Dufouil C, Huang J, Cavalieri M, Thomson R, Niessen WJ, Chibnik LB, Gislason GK,
Hofman A, Pikula A, Amouyel P, Freeman KB, Phan TG, Oostra BA, Stein JL, Medland
SE, Vasquez AA, Hibar DP, Wright MJ, Franke B, Martin NG, Thompson PM; Enhancing
Neuro Imaging Genetics through Meta-Analysis Consortium, Nalls MA, Uitterlinden
AG, Au R, Elbaz A, Beare RJ, van Swieten JC, Lopez OL, Harris TB, Chouraki V,
Breteler MM, De Jager PL, Becker JT, Vernooij MW, Knopman D, Fazekas F, Wolf PA,
van der Lugt A, Gudnason V, Longstreth WT Jr, Brown MA, Bennett DA, van Duijn CM,
Mosley TH, Schmidt R, Tzourio C, Launer LJ, Ikram MA, Seshadri S; Cohorts for
Heart and Aging Research in Genomic Epidemiology Consortium. Common variants at
12q14 and 12q24 are associated with hippocampal volume. Nat Genet. 2012 Apr