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Séminaire - Stéphane Ciocchi"Specialised projection pathways in the ventral CA1 hippocampus"

Abstract :


 The hippocampus computes diverse information involving spatial memory, anxiety, or reward and directly projects to several brain areas. Are different computations transmitted to all downstream targets uniformly, or does the hippocampus selectively route information according to content and target region? By recording from ventral hippocampal CA1 neurons in rats during different behavioral tasks and determining axonal projections with optogenetics, we observed subsets of neurons changing firing at places of elevated anxiety or changing activity during goal approach. Anxiety-related firing was selectively increased in neurons projecting to the prefrontal cortex.

Goal-directed firing was most prominent in neurons targeting the nucleus accumbens; and triple-projecting neurons, targeting the prefrontal cortex, amygdala, and nucleus accumbens, were most active during tasks and sharp wave/ripples. Thus, hippocampal neurons route distinct behavior-contingent information selectively to different target areas.

Selected publications

Camp, M.C., Macpherson, K.P., Lederle, L., Graybeal, C., Gaburro, S., Debrouse, L.M., Ihne, J.L., Bravo, J.A., O'Connor, R.M., Ciocchi, S., Wellman CL, Lüthi A, Cryan JF, Singewald N, and Holmes A. (2012). Genetic strain differences in learned fear inhibition associated with variation in neuroendocrine, autonomic, and amygdala dendritic phenotypes. Neuropsychopharmacology 37, 1534-1547.

Ciocchi, S., Lüthi, A., and Herry, C. (2011). Novel amygdala neuronal circuits controlling fear behavior. Med Sci (Paris) 27, 455-457.

Meins, M., Herry, C., Müller, C., Ciocchi, S., Moreno, E., Lüthi, A., and Monard, D. (2010). Impaired fear extinction in mice lacking protease nexin-1. Eur J Neurosci 31, 2033-2042.

Haubensak, W., Kunwar*, P.S., Cai, H.*, Ciocchi, S.*, Wall, N.R., Ponnusamy, R., Biag, J., Dong, H.W., Deisseroth, K., Callaway, E.M., Fanselow MS, Lüthi A, Anderson DJ. . (2010). Genetic dissection of an amygdala microcircuit that gates conditioned fear. Nature 468, 270-276. * equal contribution.

Ciocchi, S.*, Herry, C.*, Grenier, F., Wolff, S.B., Letzkus, J.J., Vlachos, I., Ehrlich, I., Sprengel, R., Deisseroth, K., Stadler, M.B., Müller C, Lüthi A. (2010). Encoding of conditioned fear in central amygdala inhibitory circuits. Nature 468, 277-282. * equal contribution.

Ehrlich, I., Humeau, Y., Grenier, F., Ciocchi, S., Herry, C., and Lüthi, A. (2009). Amygdala inhibitory circuits and the control of fear memory. Neuron 62, 757-771.

Herry, C.*, Ciocchi, S.*, Senn, V., Demmou, L., Muller, C., and Lüthi, A. (2008). Switching on and off fear by distinct neuronal circuits. Nature 454, 600-606. * equal contribution.

Cyril Herry / Neurocentre Magendie / (cyril.herry @ u-bordeaux.fr)