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Séminaire impromptu - Emanuela Santini & Anders BorgkvistTranslation gone awry: the role of cap-dependent protein synthesis in ASD / Dysfunctions of the striatonigral synapse in the Parkinsonian brain.

Abstract :

Emanuela Santini, PhD, New York University
Title of presentation : Translation gone awry: the role of cap-dependent protein synthesis in ASD.  Location CGFB   10h

 In 2009, I obtained my PhD at the Karolinska Institute in the laboratory of Dr. Gilberto Fisone. My aim was to understand the molecular mechanisms of L-DOPA induced dyskinesia, one of the most debilitating side effect of dopamine replacement therapy in Parkinson’s Disease. The same year I moved to United States where I joined the laboratory of Dr. Eric Klann at the New York University, where I am currently completing my studies. During these years, I became more and more interested in understanding the etiology of Autism Spectrum Disorders (ASD). In 2014 I received the K99 award from the National Institute of Health to proceed my research in Autism Spectrum Disorders, in particular I am currently investigating the onset and the neurobiology of repetitive behaviors.

My talk is centered around the discovery that increased brain protein synthesis is involved in the generation of ASD-like behavioral, structural and synaptic phenotypes in rodents. I will also present unpublished new data suggesting an involvement of striatal mGluRs receptors signaling in the induction of repetitive behaviors in ASD.


Anders Borgkvist, PhD - Columbia University
Tilte: Dysfunctions of the striatonigral synapse in the Parkinsonian brain.
Location: CGFB 14h30

 I received my PhD in Neuroscience from the Karolinska Institute in 2008. At Karolinska my research focused on characterizing the effects of cannabinoid and opioid drugs on dopamine signaling within the basal ganglia. I did a brief post-doc at Karolinska, studying the control of dopamine neurotransmission in the hippocampus, before joining the laboratory of Dr. David Sulzer at Columbia University in New York in 2009. In Dr. Sulzer’s laboratory I have developed optical methods to study individual dopamine and GABA synapses in intact brain using 2-photon microscopy.

In my talk I will show how these optical tools have provided new insights into Parkinson’s disease pathology in the basal ganglia output structure substantia nigra reticulata. My focus will be on the adaptive plasticity that develops in individual synapses of the direct pathway in response to neurodegeneration of dopamine neurons