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Séminaire impromptu - Maria Belen Pardi"Interaction between excitatory and inhibitory circuits in the recruitment of immature adult born hippocampal neurons"

Abstract :


 Adult neurogenesis in mammals continuously generates granule cells (GC) that mature and integrate into the hippocampal dentate gyrus circuitry. Although adult hippocampal neurogenesis has been implicated in cognitive processes related to spatial learning and memory, the specific role of new GC remains unclear. In this talk, I will show results from my PhD thesis work, were I studied what processing features adult-born GC provide to the circuit, and how these features are determined by inhibitory and excitatory circuits.

We propose that it is when they are still immature that adult-born GC provide unique processing capacities contributing to the hippocampal function, and that inhibitory circuits generate heterogeneity of responses among the GC populations of the dentate gyrus.

This work was done in the Neuronal Plasticity Laboratory, Leloir Institute, CONICET, Buenos Aires, Argentina and the Neuronal Circuits Laboratory, Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)- CONICET- Max Planck Society Partner (MPSP), Buenos Aires, Argentina, under the direction of Antonia Marin-Burgin and Alejandro Schinder.

My current laboratory location is Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA)- CONICET- Max Planck Society Partner (MPSP), Buenos Aires, Argentina Key words: adult neurogenesis, hippocampus, excitation/inhibition, calcium imaging, electrophysiology

Selected publications

Unique processing during a period of high excitation/inhibition balance in adult-born neurons.
Marín-Burgin A, Mongiat LA, Pardi MB, Schinder AF.Science. 2012 Mar 9;335(6073):1238-42. doi: 10.1126/science.1214956. Epub 2012 Jan 26.