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Séminaire impromptu - Emilie DoucetEffects of amphetamine and ethanol on monoaminergic transmission: insights into the neurobiology of addiction.

Abstract :

It has been previously shown by microdialysis in C57Bl/6J mice that behavioral sensitization induced by compounds belonging to main groups of drugs of abuse, such as amphetamine, cocaine, morphine, or alcohol, was underlain by a long-term sensitization of noradrenergic and serotonergic neurons.

As the main focus of my PhD, I used amphetamine to gain an insight into the mechanisms underlying the maintenance of the long-term neurochemical modifications induced by a drug of abuse. During my post-doc, I focused on studying the effects of a single in vivo ethanol exposure on GABAergic transmission in the Ventral Tegmental Area (VTA) in C57Bl/6J mice.

By providing an insight into the long-lasting neurobiological modifications induced by to drugs of abuse, we hope that our findings will help to find therapeutic targets and contribute to the development of effective treatments against drug addiction.

Selected publications

Lanteri C, Doucet EL, Bobadilla AC, Salomon L, Godeheu G, Lanfumey L and Jean-Pol Tassin. Long-term sensitization of noradrenergic and serotonergic neurons following repeated MDMA exposure. Mol Psychiatry. 2014 Jul;19(7):823-33.

 Doucet EL*, Bobadilla AC*, Houades V, Lanteri C, Godeheu G, Lamfumey L, Sara S and Tassin JP. Sustained impairment of α2A-adrenergic autoreceptor signaling mediates neurochemical and behavioral sensitization to amphetamine. Biol Psychiatry. 2013 Jul 15;74(2):90-8.

Lanteri C, Hernández Vallejo SJ, Salomon L, Godeheu G, Doucet EL, Torrens Y and Tassin JP. Inhibition of monoamine oxidases desensitizes 5-HT1A autoreceptor and allows nicotine to induce a neurochemical and behavioral sensitization. J Neurosci. 2009 Jan 28;29(4):987-97.