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Séminaire - Un cycle de séminaires neurosciences présenté par Juan P. Bolanos, Visiting Scholars.Conférences organisées par le "Centre de Résonance Magnétique des Systèmes Biologiques"

Abstract :


Le professeur Juan P. Bolanos est un Visiting Scholars de l'Université de Bordeaux. (Idex)  de l'Institute of Functional Biology and Genomics, Université de Salamanque-CSIC, une invitation et collaboration avec le Dr. Anne-Karine Bouzier-Sore  du CNRS 5536 RMSB.

 28 May 2015/ 11h CGFB  - Mitochondrial respiratory chain assembly dictates differential ROS production in neurons and astrocytes

To understand the physiological roles of reactive oxygen species (ROS) in the brain, we studied the abilities of neuronal and astrocytic mitochondria to spontaneously form ROS. We found that ROS abundance is ~one order of magnitude higher in astrocytes than in neurons, which is an unexpected observation in view that astrocytes express high levels of antioxidants. Whilst the main source of ROS in both cell types is the mitochondrial electron transport chain, these differences cannot be ascribed to the distinct abundances of total complex I –a major source of mitochondrial superoxide anion. In contrast, we found that in astrocytes a large proportion of complex I protein occurs free, whereas in neurons most complex I is assembled within electron transport chain supercomplexes. Furthermore, we show that complex I assembly into supercomplexes regulates the production of mitochondrial ROS in neurons and astrocytes. This suggests a cell-specific physiological role for mitochondrial ROS in brain cells.


 

 

Juan P. Bolanos" <jbolanos(at)usal.es>