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Conférence mensuelle - Carlos Ribeiro / PhD seminar seriesHow nutrients, neuronal circuits, and the microbiome shape nutritional

Selected publications

Kathrin Steck, Samuel J Walker, Pavel M Itskov, Célia Baltazar, José-Maria Moreira, Carlos Ribeiro (2018) Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila eLife

Leitão-Gonçalves R, Carvalho-Santos Z, Francisco AP, Fioreze GT, Anjos M, Baltazar C, Elias AP, Itskov PM, Piper MDW, Ribeiro C (2017) Commensal bacteria and essential amino acids control food choice behavior and reproduction PLoS Biol. 15 (4), e2000862

Piper MD, Soultoukis GA, Blanc E, Mesaros A, Herbert SL, Juricic P, He X, Atanassov I, Salmonowicz H, Yang M, Simpson SJ, Ribeiro C, Partridge L. (2017) Matching Dietary Amino Acid Balance to the In Silico-Translated Exome Optimizes Growth and Reproduction without Cost to Lifespan Cell Metabolism 25 (3), 610-621

Walker SJ, Corrales-Carvajal VM, Ribeiro C. (2015) Postmating Circuitry Modulates Salt Taste Processing to Increase Reproductive Output in Drosophila. Curr. Biol. 15 (pii: S0960-9822), 01014-3 [Epub ahead of print]

Itskov PM, Moreira JM, Vinnik E, Lopes G, Safarik S, Dickinson MH & Ribeiro C. (2014) Automated monitoring and quantitative analysis of feeding behaviour in Drosophila Nat Commun 5 , 4560

Scientific focus :

Nutrition is a key determinant of health, wellbeing and aging. We want to understand how animals decide what to eat and how these decisions affect the fitness of the animal. To achieve a mechanistic, integrated, whole-animal understanding of nutritional decision-making we work at the interface of behavior, metabolism and physiology in the adult fruitfly. The powerful neurogenetic tools available in model organisms allow us to identify molecular as well as circuit mechanisms involved in producing the appropriate behavioral response to a specific need of the fly. We also dedicate a significant effort to the development of novel, automated and quantitative behavioral assays to understand the behavioral strategies used by the fly to make the right nutritional decisions. The combination of powerful molecular circuit manipulations, sophisticated behavioral analyses, and imaging approaches allows for a mechanistic understanding of how neuronal circuits control nutritional decisions to regulate important traits such as aging and reproduction.