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Séminaire - Umut Ozcan

Selected publications

1) Lee J, Liu J, Feng X, Salazar Hernandez MA, Mucka P, Ibi D, Choi J, Ozcan U. Withaferin a is a leptin sensitizer with strong antidiabetic properties in mice. Nature Medicine, 2016 August 1; [PubMed]

2) Herrema H, Zhou Y, Zhang D, Salazar Hernandez MA, Shulman GI, Ozcan, U. XBP1s is an antilipogenic protein. Journal of Biological Chemistry, 2016 June 20; [PubMed]

3) Liu J, Lee J, Salazar Hernandez MA, Mazitschek R, Ozcan U. Treatment of Obesity with Celastrol. Cell, 2015 May 21; 161(5):999-1011. [PubMed]

4) Park SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC, Ozcan U. BRD7 regulates XBP1’s activity and glucose homeostasis through its interaction wit the regulatory subunits of PI3K. Cell Metabolism, 2014 Jul 1;20(1):73-84. [PubMed]

5) Cakir I, Ozcan U. Mom’s milk molds neural wiring for metabolism. Cell, 2014 Jan 30;156(3):396-7. [PubMed]

6) Lee J, Ozcan U. Unfolded protein response signaling and metabolic diseases. J Biol Chem, 2014 Jan 17;289(3):1203-11. [PubMed]

7) Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res Commun, 2014 Jan 10;443(2):689-93. [PubMed]

8) Ozcan U. Mitofusins: mighty regulators of metabolism. Cell, 2013 Sep 26;155(1):17-8. [PubMed]

9) Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Nature Medicine, 2011 Sep 4;17(10):1251-60 [PubMed]

10) Zhou Y, Lee J, Reno CM, Chung J, Sun C, Park SW, Chung J, Lee J, White MF, Biddinger S, Fisher SJ, Ozcan U. Regulation of Glucose Homeostasis Through XBP1-FoxO1 interaction. Nature Medicine, 2011 Mar;17(3):356-65. [PubMed]

11) Park S, Zhou Y, Lee J, Lee J, Ozcan U. Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress and glucose homeostasis in obesity. PNAS, 2010 Nov 9;107(45):19320-5. [PubMed]

12) Park S, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nature Medicine, 2010 Apr;16(4):429. [PubMed]

13) Ozcan L, Ergin AS, Sarkar S, Lu A, Chung J, Nie D, Myers MG, Jr., Ozcan U. Endoplasmic Reticulum Stress Plays A Central Role in Development of Leptin Resistance. Cell Metabolism, 2009 Jan 7;9(1):35-51. [PubMed]

Scientific focus :

Ozcan Laboratory is a multi-national team dedicated to the understanding and treatment of obesity and obesity-related diseases. Our laboratory is located within the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School. The primary aim of the laboratory is to delineate the molecular mechanisms of endoplasmic reticulum (ER) stress originated pathologies in obesity. The two main focus areas are insulin and leptin receptor signaling and their crosstalk with the unfolded protein response pathway. Dr. Ozcan's group employ a multi-disciplinary approach that draws on mouse genetics, endoplasmic reticulum physiology & pathophysiology, biochemistry, chemical biology and proteomics to identify key metabolic pathways that determine the cell’s response to physiologic and pathophysiologic ER stress. The ultimate goal of this integrated approach is to unravel the potential therapeutic targets in the unfolded protein response (UPR) pathway in order to manipulate cellular energy metabolism and find a cure for obesity and its related diseases.