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Séminaire impromptu - Robin Hiesinger //annulé !!! Simple rules in neural circuit assembly

Abstract :


 How much information is required to wire up a brain?  Hiesinger and colleagues take an algorithmic approach to brain wiring based on live observation of how connections are made in the fly visual system:
  First, non-invasive imaging of neural circuit assembly at high resolution allows to identify (often surprisingly simple) algorithmic rules that can generate complicated wiring diagrams with precision, robustness, and flexibility. 
Second, genetic perturbation allows to identify the cell interaction molecules that execute these rules. A hallmark of such rules and their molecular execution is that they rely on stochastic dynamic processes that seem, at first glance, at odds with the idea of deterministic molecular synaptic targets. 
Two questions therefore motivate Hiesinger’s current work and will be addressed in the talk: To what extent can simple algorithmic rules determine neural circuit assembly before molecular synaptic target definitions become indispensable? And how is robust circuit assembly ensured based on stochastic developmental processes?

Selected publications

1: Jin EJ, Kiral FR, Hiesinger PR. The where, what, and when of membrane protein 
degradation in neurons. Dev Neurobiol. 2017 Sep 7. doi: 10.1002/dneu.22534. [Epub
ahead of print] Review. PubMed PMID: 28884504.
2: Kolodkin AL, Hiesinger PR. Wiring visual systems: common and divergent
mechanisms and principles. Curr Opin Neurobiol. 2017 Feb;42:128-135. doi:
10.1016/j.conb.2016.12.006. Epub 2017 Jan 5. Review. PubMed PMID: 28064004;
PubMed Central PMCID: PMC5316370.
3: Özel MN, Langen M, Hassan BA, Hiesinger PR. Filopodial dynamics and growth
cone stabilization in Drosophila visual circuit development. Elife. 2015 Oct
29;4. pii: e10721. doi: 10.7554/eLife.10721. PubMed PMID: 26512889; PubMed
Central PMCID: PMC4728134.
4: Hassan BA, Hiesinger PR. Beyond Molecular Codes: Simple Rules to Wire Complex 
Brains. Cell. 2015 Oct 8;163(2):285-91. doi: 10.1016/j.cell.2015.09.031. Review. 
PubMed PMID: 26451480; PubMed Central PMCID: PMC4600127.
5: Langen M, Agi E, Altschuler DJ, Wu LF, Altschuler SJ, Hiesinger PR. The
Developmental Rules of Neural Superposition in Drosophila. Cell. 2015 Jul
2;162(1):120-33. doi: 10.1016/j.cell.2015.05.055. Epub 2015 Jun      25. PubMed PMID: 
26119341; PubMed Central PMCID: PMC4646663.