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Séminaire - Junichi Nabekura

Abstract :

We are interested in the activity-dependent development and reorganization of neuronal circuits in the central nervous system. A lot of neuronal networks are reshaped by experiences during early postnatal life. The similar neuronal reorganization can be seen after nerve injury. What happens at the level of neural networks including synaptic formation and function during postnatal development and recovery period from nerve injury? To address these questions, we study the central nervous system in rodents. Techniques applied in our laboratory include in vivo two-photon microscopy, immunohistochemistry, electrophysiological and molecular biological techniques.

Selected publications

Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J. J Clin Invest. 2016 May 2;126(5):1983-97.

*Microglia contact induces synapse formation in developing somatosensory cortex.
Miyamoto A, Wake H, Ishikawa AW, Eto K, Shibata K, Murakoshi H, Koizumi S, Moorhouse AJ, Yoshimura Y, Nabekura J. Nat Commun. 2016 Aug 25;7:12540.