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Séminaire - Marco VenniroVolitional social interaction prevents drug addiction in rat models

Abstract :

Addiction treatment has not been appreciably improved by neuroscientific research. One problem is that mechanistic studies using rodent models do not incorporate volitional social factors, which play a critical role in human addiction.
Using rats, we introduced an operant model of choice between drugs and social interaction. Independent of sex, drug class, drug dose, training conditions, abstinence duration, social housing, or “addiction score” in the DSM-IV-based and intermittent access models, operant social reward prevented drug self-administration.
This protection was lessened by delay or punishment of the social reward but neither measure was correlated with the “addiction score.” Social choice-induced abstinence also prevented incubation of methamphetamine craving. This protective effect was associated with activation of central amygdala PKCδ-expressing inhibitory neurons and inhibition of anterior insular cortex activity.
These findings highlight the need for incorporating social factors into neuroscience-based addiction research and support the wider implantation of socially based addiction treatments.

Selected publications

Venniro M, Zhang M, Caprioli D, Hoots JK, Golden SA, Heins C, Morales M, Epstein DH, Shaham Y. (2018). Volitional social interaction prevents drug addiction in rat models. Nature Neuroscience, In press (Selected for the Cover of the November 2018 issue).

Venniro M, Caprioli D, Shaham Y. (2018). Novel models of drug relapse and craving after voluntary abstinence. Neuropsychopharmacology, 0:1–2; doi.org/10.1038/s41386-018-0196-4.

Venniro M, Caprioli D, Zhang M, Whitaker LR, Zang S, Warren BL, Cifani C, Marchant NJ, Yizhar O, Bossert JM, Chiamulera C, Morales M, Shaham Y. (2017). The anterior insular cortex à central amygdala glutamatergic pathway is critical to relapse after contingency management. Neuron, 96(2):414-427.

Caprioli D*, Venniro M*, Zhang M, Bossert JM, Warren BL, Hope BT, Shaham Y. (2017). Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence. J Neurosci, 37(4):1014-1027. *Co-first authors.

Venniro M, Zhang M, Shaham Y, Caprioli D. (2017). Incubation of methamphetamine but not heroin craving after voluntary abstinence in male and female rats. Neuropsychopharmacology, 42(5):1126-1135.

Venniro M, Caprioli D, Shaham Y. (2016) Animal models of drug relapse: from drug priming induced reinstatement to incubation of craving after voluntary abstinence. Progress in Brain Research, 224:25-52.