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Séminaire impromptu - Luc Estebanez"Bridging sensory and motor: a fast intracortical brain-machine interface with patterned optogenetic feedback"

Abstract :


 Somatosensory input plays a critical role in limb movement control.
But so far, little is known about the way it is processed and integrated into motor commands. In particular, in the primary motor cortex (M1), somatosensory responses and motor activity have both been observed, but the link between these two components is unknown.

What makes this study particularly challenging is the lack of clear causal link between M1 activity and mouse behaviour, as well as the difficulty to provide controlled somatosensory input to a behaving animal.

To address this issue we have developed in the head-fixed mouse a brain-machine interface (BMI) that establishes a causal link between M1 activity and a controlled behaviour. To fully control somatosensory-like inputs to M1, this BMI includes a low-latency, artificial somatosensory-like feedback directly into the barrel cortex.

Beyond its use as a research platform, this BMI with feedback constitutes a preclinical research model of somatosensory-enabled medical BMIs, which are expected to sharply improve on the performance of current generation, no-feedback BMIs.

Selected publications

 Luc Estebanez, Diana Hoffmann, Birgit C. Voigt and James F A Poulet, Parvalbumin-Expressing GABAergic Neurons in Primary Motor Cortex Signal Reaching, Cell Reports 20: 308-318, (2017) [pdf]

Luc Estebanez, Isabelle Ferezou, Valerie Ego-Stengel and Daniel Shulz, Representation of tactile scenes in the rodent barrel cortex, Neuroscience 368: 81-94, (2017) [pdf] 

Scientific focus :

Comment s’effectue l’intégration sensori-motrice dans le cerveau ? Comment est-ce que l’information issue de scènes sensorielles complexes est transformé en commandes motrices multidimensionnel ? Pour répondre à cette question, j’ai étudié les aspects sensoriels et moteurs de la boucle sensori-motrice pendant ma thèse et mes post-docs, et je développe actuellement une interface cerveau-machine avec retour sensoriel qui s’appuie sur ce travail.
Avec deux doctorants de l’équipe — Aamir Abbasi et Dorian Goueytes — je mets actuellement en place une interface cerveau-machine chez la souris tête fixée, basée sur la lecture de l’activité dans le cortex moteur primaire et sur un retour sensoriel par stimulation optogénétique patternée des neurones du cortex somatosensoriel primaire.