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Séminaire impromptu - Laura CorbitEffects of drug use, stress and diet on the control of habitual versus goal-directed behavior by dorsal striatal subregions

Abstract :

 In order to adapt to its environment, an animal must be sensitive to the consequences of its actions and be able to modify its behaviour
in order to gain access to desired commodities while avoiding events that are harmful or aversive. It is the flexibility of the instrumental or goal-directed components of human behaviour that allows us to develop new behavioural strategies to control events in our environment and satisfy our needs. The adaptive quality of this flexibility becomes most clear when these processes break down as they do in a number of psychiatric disorders including addiction. The goal of my research is to provide fundamental information about the behavioural and neural determinants of goal-directed action and the transition to automatic/habitual performance. This work will also provide considerable insight into the development and maintenance of addictive behaviours and may aid the development of treatment strategies to reverse such behaviours.

Selected publications

Noradrenergic β-receptor antagonism in the basolateral amygdala impairs reconsolidation, but not extinction, of alcohol self-administration: Intra-BLA propranolol impairs reconsolidation of alcohol self-administration. Chesworth R, Corbit LH. Neurobiol Learn Mem. 2018 May;151:59-70. doi: 10.1016/j.nlm.2018.04.009. Epub 2018 Apr 9.

Recent developments in the behavioural and pharmacological enhancement of extinction of drug seeking.Chesworth R, Corbit LH.Addict Biol. 2017 Jan;22(1):3-43. doi: 10.1111/adb.12337. Epub 2015 Dec 21. Review. PMID: 26687226

Habitual Alcohol Seeking: Neural Bases and Possible Relations to Alcohol Use Disorders. Corbit LH, Janak PH. Alcohol Clin Exp Res. 2016 Jul;40(7):1380-9. doi: 10.1111/acer.13094. Epub 2016 May 25. Review. PMID: 27223341 Free PMC Article