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Conférence mensuelle - Juan Burrone: PhD seminar seriesMapping Synaptic Contacts: From Dendrites to the Axon Initial Segment

Abstract :

Neurons in the brain have extensive dendritic arbours that receive both excitatory and inhibitory inputs all along it. The transformation of all these inputs to an output in a single neuron occurs through the integration of synaptic events and the generation of an action potential (or spike) at the axon initial segment. This talk will discuss the properties of both the inputs (synapses) and outputs (axon initial segment) of pyramidal neurons in the cortex.
The first part of the talk will focus on the distribution of synapses along the vast dendritic tree of pyramidal neurons and examine the functional consequences of these arrangements.
The second part of the talk will focus on the plasticity of the axon initial segment and of the GABAergic synapses form onto this domain, to begin to uncover how neuronal output can be modulated in the brain.
Our overall goal is to be able to bring these areas of research together to properly understand how inputs are converted into outputs by neurons in the brain.

Selected publications

Grillo, F, Neves G, Walker, A, Vizcay G, Fleck R, Branco T, Burrone J. (2018). A distance-dependent distribution in presynaptic structure and function tunes frequency-dependent dendritic integration. Neuron, 99: 275-282.

 Walker, A., Neves, G., Grillo, F., Jackson., RE., Rigby, M., Lowe, A., O’Donnell, C., Vizcay, G., Fleck, R., Burrone, J. (2017) A distance-dependent gradient in NMDAR-driven spine calcium signals along tapering dendrites. Proc Natl Acad Sci U S A, 114: E1986-95.

 Wefelmeyer W, Cattaert D, Burrone J. (2015) Activity-dependent mismatch between axo-axonic synapses and the axon initial segment controls neuronal output. Proc Natl Acad Sci U S A., 112(31):9757-62. 

Grubb MS and Burrone J. (2010). Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. Nature, 465: 1070-1074.

PhD seminar series and pizzas

La Fédération Bordeaux Neurocampus, en concertation avec l'Ecole Doctorale SVS, a mis en place une série de conférences destinée à l'ensemble des étudiants effectuant leur thèse dans les laboratoires de neurosciences de Bordeaux Neurocampus. Les doctorants Neuroscience in Bordeaux Association (NBA)sont chargés de l'organisation.

Modalités : tous les premiers vendredi de chaque mois à 11h30 (durée : 1h), puis pizzas avec les étudiants et rencontres avec les personnes intéressées l'après-midi

If you are interested to share pizzas and a good moment with the speaker (12h30 - 14h),please register on this Doodle : (maximum 15 people, first-come-first-served!)