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Conférence mensuelle - Ingo GREGERUnderstanding AMPA receptor structural dynamics at synapses

Abstract :

AMPA-type glutamate receptors (AMPARs) are tetrameric cation channels that are central to synaptic transmission and plasticity at excitatory synapses. Accumulation of AMPARs at synaptic sites mediates synaptic potentiation, a process that ultimately underlies learning. Recent progress in AMPAR structural biology and receptor simulations using computational approaches together with electrophysiology have resulted in a deeper understanding of the mechanics underlying operation of this dynamic signalling machine (the AMPAR).
In this talk I will discuss recent insights into the structural dynamics of AMPARs and how these could play a role in synaptic anchoring. A key function of the AMPAR N-terminal domain (NTD) in subsynaptic localization of the receptor will be discussed.

Selected publications

Synaptic transmission and plasticity require AMPA receptor anchoring via its N-terminal domain. Watson JF, Ho H, Greger IH. Elife. 2017 Mar 14;6. pii: e23024. doi: 10.7554/eLife.23024.

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins. Greger, I.H., Watson, J.F., Cull-Candy, S.G. (2017) Neuron 94: (4):713-730.

Structure and organization of heteromeric AMPA-type glutamate receptors. Herguedas, B., García-Nafría, J., Cais, O., Fernández-Leiro, R., Krieger, J., Ho, H. and Greger, I.H. (2016). Science 352: (6285):aad3873.

Mapping the interaction sites between AMPA receptors and TARPs reveals a role for the receptor N-terminal domain in channel gating. Cais, O., Herguedas, B., Krol, K., Cull-Candy, S.G., Farrant, M. and Greger, I.H. (2014) . Cell Rep. 9: 728-40

Activity-mediated AMPA receptor remodeling, driven by alternative splicing in the ligand-binding domain. Penn, A.C., Balik, A., Wozny, C., Cais, O. and Greger I.H. (2012) Neuron 76: 530-10

Dynamics and allosteric potential of the AMPA receptor N-terminal domain. Sukumaran, M., Rossmann, M., Dutta, A., Shrivstava, I., Bahar, I. and Greger, I.H. (2011)
EMBO J 30: 972-82.

 

PhD seminar series

La Fédération Bordeaux Neurocampus, en concertation avec l'Ecole Doctorale SVS, met en place une série de conférences destinée à l'ensemble des étudiants effectuant leur thèse dans les laboratoires de neurosciences de Bordeaux Neurocampus. Les doctorants Neuroscience in Bordeaux Association (NBA) sont chargés de l'organisation. 

Modalités : tous les premiers vendredi de chaque mois à 11h30 (durée : 1h), puis pizzas avec les étudiants et rencontres avec les personnes intéressées l'après-midi

If you are interested to share pizzas and a good moment with him (12h30 - 14h), please register on this Doodle : soon) (maximum 15 people, first-come-first-served!)