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Séminaire - Heinz Beck Mechanisms of sparse coding in the dentate gyrus

Abstract :

The dentate gyrus is the most important relay station that transfers polysensory information from the entorhinal cortex into the hippocampus proper. Theoretical and experimental evidence suggests that sparse coding of granule cells is critical for the ability to discriminate similar sensory percepts. The talk will explore some intriguing properties of the dentate gyrus that support sparse coding. Firstly, unique features of the granule cell dendrites confer strong attenuation and linear integrative properties onto granule cells. Secondly, dentate granule cells are powerfully modulated by canonical GABAergic inhibition and cholinergic modulation in-vitro and in-vivo. The presentation will discuss how these mechanisms can be used to shape state-dependent input-output processing in the dentate gyrus. 

 

Selected publications

Pabst, M., Braganza, O., Dannenberg, H., Rosen, J., van Loo, K., Deisseroth, K., Schoch, S., Becker, A., Beck, H. (2016) Astrocytic intermediaries of septohippocampal cholinergic transmission. Neuron, 90, 1–13.

Krüppel, R., Remy, S., Beck, H. (2011) Dendritic integration in hippocampal dentate granule cells. Neuron, 71:512-528.1.