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Conférence mensuelle - Gero Miesenböck / PhD seminar seriesOPTOGENETICS: LIGHTING UP THE BRAIN

Abstract :

In a decade and a half, optogenetic control of neuronal activity has developed from a far-fetched idea to a widely used technique for probing the neural substrates of cognition and behavior. My talk will recount how this happened, drawing on the earliest and latest results from my lab. To illustrate what is now possible, I will present recent work on the homeostatic regulation of sleep. Optogenetics has allowed us to pinpoint neurons whose sleep-inducing activity switches on as sleep deficits accrue, understand how this activity switch works, and map some of the efferent connections that impose sleep on the rest of the brain.

Selected publications

Zemelman, B.V., Lee, G.A., Ng, M., and Miesenböck, G. (2002) Selective photostimulation of genetically chARGed neurons. Neuron 33: 15–22.

Lima, S.Q., and Miesenböck, G. (2005) Remote control of behavior through genetically targeted photostimulation of neurons. Cell 121: 141–152.

Donlea, J.M., Pimentel, D., and Miesenböck, G. (2014) Neuronal machinery of sleep homeostasis in Drosophila. Neuron 81: 860–872.

Pimentel, D., Donlea, J.M., Talbot, C.B., Song, S.M., Thurston, A.J.F., and Miesenböck, G. (2016) Operation of a homeostatic sleep switch. Nature 536: 333–337.

Donlea, J.M., Pimentel, D., Talbot, C.B., Kempf, A., Omoto, J.J., Hartenstein, V., and Miesenböck, G. (2018) Recurrent circuitry for balancing sleep need and sleep. Neuron 97: 378–389.

Scientific focus :

Gero Miesenböck is Waynflete Professor of Physiology and founding Director of the Centre for Neural Circuits and Behaviour at the University of Oxford. Before coming to Oxford in 2007, he held faculty appointments at Memorial Sloan-Kettering Cancer Center and Yale University. Miesenböck has received many awards for the invention of optogenetics, including the Brain Prize, the Heinrich Wieland Prize, the BBVA Foundation Frontiers of Knowledge Award, and the Massry Prize. He is a member of the Austrian and German Academies of Sciences and a Fellow of the Royal Society.

PhD seminar series and... pizzas

La Fédération Bordeaux Neurocampus, en concertation avec l'Ecole Doctorale SVS, a mis en place une série de conférences destinée à l'ensemble des étudiants effectuant leur thèse dans les laboratoires de neurosciences de Bordeaux Neurocampus. Les doctorants Neuroscience in Bordeaux Association (NBA) sont chargés de l'organisation.

Modalités : tous les premiers vendredi de chaque mois à 11h30 (durée : 1h), puis pizzas avec les étudiants et rencontres avec les personnes intéressées l'après-midi

If you are interested to share pizzas and a good moment with the speaker (12h30 - 14h), please register on this Doodle : soon) (maximum 15 people, first-come-first-served!)