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Séminaire impromptu - Eric WohlebMolecular and neurophysiological pathways that promote microglia-mediated neuronal remodeling in response to chronic stress

Abstract :

The talk will expound on our initial report that showed chronic stress increased CSF1 signaling in the medial PFC, leading to microglial phagocytosis of neuronal elements that contribute to synaptic deficits and development of depressive-like behaviors (Wohleb et al, Biological Psychiatry, 2017). New results show that chronic stress-induced glucocorticoid signaling and increased neuronal activation in the medial PFC promote CSF1 signaling and functional changes in microglia. Preliminary studies also show divergent sex-dependent and laminar-specific microglial responses to chronic stress, which may underlie different behavioral and cognitive impairments.

Selected publications

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior. Wohleb ES, Terwilliger R, Duman CH, Duman RS. Biol Psychiatry. 2018 Jan 1;83(1):38-49. doi: 10.1016/j.biopsych.2017.05.026. Epub 2017 Jun 12. PMID: 28697890

Neuron-Microglia Interactions in Mental Health Disorders: "For Better, and For Worse". Wohleb ES. Front Immunol. 2016 Nov 29;7:544. eCollection 2016. Review.

Integrating neuroimmune systems in the neurobiology of depression. Wohleb ES, Franklin T, Iwata M, Duman RS.Nat Rev Neurosci. 2016 Aug;17(8):497-511. doi: 10.1038/nrn.2016.69. Epub 2016 Jun 9. Review.