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Conférence mensuelle - PhD seminar series Clément LenaThe dialog between the cerebellum and the sensori-motor cortices.

Abstract :

The cerebellum contains more than half of the brain neurons and this proportion has been steadily maintained along with the expansion of the cerebral cortex, by the evolution of the mammalian brain. Indeed, the cerebellum and cerebral cortex are reciprocally connected. The cerebellum, long thought as a motor structure, is now recognized as a key player in a much wider spectrum of brain functions, and cerebellar dysfunction in the early life is a strongly suspected cause of autism-spectrum disorder. The nature of the dialog between the cerebellum and the cerebral cortex is currently poorly understood; for a long time, this dialog has been proposed to rely on closed loops between specific cortical and cerebellar areas. Using a combination of tracing, neurophysiology, chemo- and opto-genetics and behavioral studies, our recent work has expanded this view by showing that the cerebellum is indeed interacting with cortical networks and that multiple modes of interaction with the cerebral cortex underly the diversity of functional roles of the cerebellum.

Brief Vitae: 1992-1997 PhD in Molecular and Cellular Pharmacology (UPMC) under the direction of JP Changeux (Institut Pasteur, Paris) 1999-2001 postdoc in Wilson Lab (MIT, Cambridge, MA) 2001-2003 INSERM researcher (Institut Pasteur Paris) 2003-present INSERM reserarcher Department of Biology (ENS, Paris) 2016-present group leader at the IBENS (ENS, Paris)

Selected publications

Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements.Proville RD, Spolidoro M, Guyon N, Dugué GP, Selimi F, Isope P, Popa D, Léna C.Nat Neurosci. 2014 Sep;17(9):1233-9. doi: 10.1038/nn.3773. Epub 2014 Jul 27.

Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge.Chaumont J, Guyon N, Valera AM, Dugué GP, Popa D, Marcaggi P, Gautheron V, Reibel-Foisset S, Dieudonné S, Stephan A, Barrot M, Cassel JC, Dupont JL, Doussau F, Poulain B, Selimi F, Léna C, Isope P.Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16223-8. doi: 10.1073/pnas.1302310110. Epub 2013 Sep 17.

Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice.Dugué GP, Lörincz ML, Lottem E, Audero E, Matias S, Correia PA, Léna C, Mainen ZF.PLoS One. 2014 Aug 22;9(8):e105941. doi: 10.1371/journal.pone.0105941. eCollection 2014.

α-synuclein assemblies sequester neuronal α3-Na+/K+-ATPase and impair Na+ gradient.Shrivastava AN, Redeker V, Fritz N, Pieri L, Almeida LG, Spolidoro M, Liebmann T, Bousset L, Renner M, Léna C, Aperia A, Melki R, Triller A.EMBO J. 2015 Oct 1;34(19):2408-23. doi: 10.15252/embj.201591397. Epub 2015 Aug 31.



La Fédération Bordeaux Neurocampus, en concertation avec l'Ecole Doctorale SVS, a mis en place une série de conférences destinée à l'ensemble des étudiants effectuant leur thèse dans les laboratoires de neurosciences de Bordeaux Neurocampus. Les doctorants Neuroscience in Bordeaux Association (NBA)sont chargés de l'organisation.

Modalités : tous les premiers vendredi de chaque mois à 11h30 (durée : 1h), puis pizzas avec les étudiants et rencontres avec les personnes intéressées l'après-midi

If you are interested to share pizzas and a good moment with the speaker (12h30 - 14h),please register on this Doodle : (maximum 15 people, first-come-first-served!)