5ème conférence mensuelle 2016-2017
The cerebellum or ‘little brain’ is a major site of sensorimotor integration and contains more than half of all the neurons in the mammalian brain. The elegant repeating circuitry of the cerebellar cortex has led to its description as ‘a neuronal machine’, but we know surprising little about its function. In particular our understanding of how the circuit encodes associated sensory and motor information during behaviour remains limited. We have approached this problem by using a well-defined model, the mouse vibrissae system, to study how sensorimotor signals are represented by the activity of individual neurons within the cerebellar cortex. In this talk I will describe how whisking behaviour is encoded by neurons in both input and output layers of the cerebellar cortex. Our results reveal that cells in the cerebellum use a simple code to represent whisker position during voluntary movement and provide a powerful new platform to explore neural computations underlying sensorimotor behavior.
CO-MODULATION ENHANCES SIGNAL DETECTION VIA PRIMING OF AUDITORY CORTICAL CIRCUITS J Sollini, P Chadderton (2016). Journal of Neuroscience in press
THE CEREBELLUM LINEARLY ENCODES WHISKER POSITION DURING VOLUNTARY MOVEMENT S Chen, GJ Augustine, P Chadderton (2016). eLife 5: e10509
SENSORY-EVOKED SYNAPTIC INTEGRATION IN CEREBELLAR AND CEREBRAL CORTICAL NEURONS P Chadderton, AT Schaefer, SR WIlliams & T Margrie (2014). Nature Reviews Neuroscience 15: 71-83.
THE SYNAPTIC REPRESENTATION OF SOUND SOURCE LOCATION IN PRIMARY AUDITORY CORTEX P Chadderton, JP Agapiou, D McAlpine & TW Margrie (2009). Journal of Neuroscience 29: 14127-14135.
HIGH FIDELITY TRANSMISSION OF SENSORY INFORMATION BY SINGLE CEREBELLAR MOSSY FIBRE BOUTONS E Rancz*, T Ishikawa*, I Duguid*, P Chadderton*, S Mahon & M Häusser (2007). Nature 450: 1245-1248 (*equal contributors).
INTEGRATION OF QUANTA DURING SENSORY PROCESSING IN CEREBELLAR GRANULE CELLS P Chadderton, TW Margrie & M Häusser (2004). Nature 428: 856-860.
Scientific focus :
The brain is composed of billions of neurons that are intricately connected within small circuits. We are interested in the roles that these circuits play in sensory perception and behaviour. To do this, we record the electrical activity of single cells and small populations, combining advanced electrophysiology and molecular tools to record and manipulate neuronal activity in behaving animals.
We are especially interested in how the circuits of neocortex and cerebellum combine information from the outside world (the senses) with internally generated signals (thoughts and intentions) to appropriately guide behaviour. Our goal is to understand how computation by neural circuits is applied in the representation of the external and internal world.