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Séminaire impromptu - Patrik RorsmanDysregulated glucagon secretion: A membrane transport perspective

Abstract :

 We study cellular physiology of pancreatic islets
 – the small organs that regulate the whole-body sugar levels. Our work will help to find new treatments for diabetes – a disease that is characterised by uncontrolled blood sugar.

In the Rorsman lab, using human and rodent islets, we are studying the precise mechanisms that control pancreatic hormone secretion. Over years of research, we have developed electrophysiological, optical imaging and biochemical techniques that enabled us to monitor the electrical signals, intracellular Ca2+ and cell exocytosis in the islet cells with great detail and at ultrahigh resolution.  read more...

Selected publications

[1] K. Philippaert, A. Pironet, M. Mesuere, W. Sones, L. Vermeiren, S. Kerselaers, S. Pinto, A. Segal, N. Antoine, C. Gysemans, J. Laureys, K. Lemaire, P. Gilon, E. Cuypers, J. Tytgat, C. Mathieu, F. Schuit, P. Rorsman, K. Talavera, T. Voets, R. Vennekens, Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity, Nat Commun, 8 (2017) 14733.

[2] B. Hastoy, P.A. Scotti, A. Milochau, Z. Fezoua-Boubegtiten, J. Rodas, R. Megret, B. Desbat, M. Laguerre, S. Castano, D. Perrais, P. Rorsman, R. Oda, J. Lang, A Central Small Amino Acid in the VAMP2 Transmembrane Domain Regulates the Fusion Pore in Exocytosis, Sci Rep, 7 (2017) 2835.

[3] N.R. Gandasi, P. Yin, M. Riz, M.V. Chibalina, G. Cortese, P.E. Lund, V. Matveev, P. Rorsman, A. Sherman, M.G. Pedersen, S. Barg, Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes, J Clin Invest, 127 (2017) 2353-2364.

[4] S.E. Cross, R.H. Vaughan, A.J. Willcox, A.J. McBride, A.A. Abraham, B. Han, J.D. Johnson, E. Maillard, P.A. Bateman, R.D. Ramracheya, P. Rorsman, K.E. Kadler, M.J. Dunne, S.J. Hughes, P.R. Johnson, Key Matrix Proteins Within the Pancreatic Islet Basement Membrane Are Differentially Digested During Human Islet Isolation, Am J Transplant, 17 (2017) 451-461. [5] L.J.B. Briant, T.M. Reinbothe, I. Spiliotis, C. Miranda, B. Rodriguez, P. Rorsman, delta-cells and beta-cells are electrically coupled and regulate alpha-cell activity via somatostatin, J Physiol, (2017).

Short Bio

Patrik Rorsman obtained his PhD at Uppsala University in 1986 and then worked for extended periods in the laboratory of Bert Sakmann (Nobel Prize 1991), where he learnt the patch-clamp technique, which has remained a work horse of his research ever since. After a brief period at Novo Nordisk in Denmark (1994-97), he became Professor of Physiology at Lund University. He is currently Professor of Diabetic Medicine at the University of Oxford and Professor, Department of Physiology, University of Gothenburg. He has published 395 articles which have been widely cited. He was awarded the Minkowski Prize (in 1996) and the Albert Renold Prize (2013) of the European Association for the Study of Diabetes and was elected Fellow of Royal Society (FRS) in 2014