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Séminaire impromptu - Jeffrey S Diamond“Diverse synaptic signaling in retinal amacrine cells”

Abstract :


Our laboratory seeks to understand how the brain receives, computes, encodes and transmits information.
More specifically, we’d like to learn which biophysical and morphological features equip synapses, neurons and networks to perform these tasks. The retina is a model system for the study of neuronal information processing: We can deliver precisely defined physiological stimuli and record with high fidelity the output of the retina, as well as activity at various points within the network; in addition, retinal circuitry is particularly well understood, enabling us to interpret more directly the impact of synaptic and cellular mechanisms on circuit function; finally, new genetic tools permit us to identify specific neuronal subtypes, record their activity and manipulate their influence on the network. I will present recent experiments in the lab that exploit these advantages to examine how synapses and neurons within the retinal circuit perform specific visual computations.

Selected publications

Species-specific wiring for direction selectivity in the mammalian retina
Article · Jun 2016 · Nature

Retinal Circuitry Balances Contrast Tuning of Excitation and Inhibition to Enable Reliable Computation of Direction Selectivity
Full-text available · Article · May 2016 · The Journal of Neuroscience

NMDA Receptors Multiplicatively Scale Visual Signals and Enhance Directional Motion Discrimination in Retinal Ganglion Cells
Article · Mar 2016 · Neuron