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Séminaire - Diego Alvarez"I could use some feedback..."

Abstract :

 Experience shapes the development and connectivity of adult-born granule cells (GCs) through mechanisms that are poorly understood. We examined the remodeling of dentate gyrus microcircuits in mice in an enriched environment (EE). Short exposure to EE during early development of new GCs accelerated their functional integration. This effect was mimicked by in vivo chemogenetic activation of a limited population of mature GCs. Slice recordings showed that mature GCs recruit parvalbumin g-aminobutyric acid-releasing interneurons (PV-INs) that feed back onto developing GCs. Accordingly, chemogenetic stimulation of PV-INs or direct depolarization of developing GCs accelerated GC integration, whereas inactivation of PV-INs prevented the effects of EE. Our results reveal a mechanism for dynamic remodeling in which experience activates dentate networks that “prime” young GCs through a disynaptic feedback loop mediated by PV-INs.

Selected publications

- Silvio G. Temprana, Lucas A. Mongiat, Sung M. Yang, Mariela F. Trinchero, Diego D. Alvarez, Emilio Kropff, Damiana Giacomini, Natalia Beltramone, Guillermo M. Lanuza, and Alejandro F. Schinder: “Delayed Coupling to Feedback Inhibition during a Critical Period for the Integration of Adult-Born Granule Cells”; Neuron, Jan 2015.

- Diego D. Alvarez, Sung M. Yang, Alejandro F. Schinder:. “Reliable genetic labeling of adult-born dentate granule cells using Ascl1CreERT2 and GLASTCreERT2 murine lines”; The Journal of Neuroscience, Nov 2015.

- Diego D. Alvarez, Damiana P. Giacomini, Sung M. Yang, Mariela F. Trinchero, Alejandro F. Schinder: “Activity-dependent maturation of adult-born dentate granule cells”; Science, Oct 2016.

Scientific focus :

I am interested in the study of the cellular and molecular mechanisms involved in learning and memory. In particular, I am very interested in the activity-dependent plasticity mechanisms taking place in the hippocampus and cortex, and the principles of cell-cell communication. I am also very interested in the study of neurological diseases, in particular those affecting childhood and adolescence.