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Séminaire impromptu - John F Cryan“A Gut Feeling About the Brain: Microbiome as a Key Regulator of Neurodevelopment and Behaviour”

Abstract :

Prof. Cryan's current research interests include the neurobiological basis of stress-related neuropsychiatric disorders including depression, anxiety and drug dependence. Moreover, his group is also focused on understanding the interaction between brain, gut & microbiome and how it applies to stress and immune-related disorders, including irritable bowel syndrome and obesity and neurodevelopmental disorders such as autism. He is also interested in applying novel approaches to facilitate drug/siRNA delivery to the brain in vivo.

Selected publications

Luczynski P, Tramullas M, Viola M, Shanahan F, Clarke G, O'Mahony S, Dinan TG, Cryan JF. Microbiota regulates visceral pain in the mouse. Elife. 2017 Jun 20;6. pii: e2588

The microbiome regulates amygdala-dependent fear recall. Hoban AE, Stilling RM, Moloney G, Shanahan F, Dinan TG, Clarke G, Cryan JF. Mol Psychiatry. 2017 May 16.

Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice. Burokas A, Arboleya S, Moloney RD, Peterson VL, Murphy K, Clarke G, Stanton C, Dinan TG, Cryan JF. Biol Psychiatry. 2017 Feb 24. pii: S0006-3223(17)30042-2.

Gut-brain axis in 2016: Brain-gut-microbiota axis - mood, metabolism and behaviour. Dinan TG, Cryan JF. Nat Rev Gastroenterol Hepatol. 2017 Feb;14(2):69-70.

Adult Hippocampal Neurogenesis Is Regulated by the Microbiome. Ogbonnaya ES, Clarke G, Shanahan F, Dinan TG, Cryan JF, O'Leary OF. Biol Psychiatry. 2015 Aug 15;78(4):e7-9.

Toll-like receptor 4 regulates chronic stress-induced visceral pain in mice. Tramullas M, Finger BC, Moloney RD, Golubeva AV, Moloney G, Dinan TG, Cryan JF. Biol Psychiatry. 2014 Aug 15;76(4):340-8. doi:

Microbiota is essential for social development in the mouse.Mol Psychiatry. 2014 Feb;19(2):146-8. doi: 10.1038/mp.2013.65. Epub 2013 May 21. Desbonnet L1, Clarke G2, Shanahan F3, Dinan TG2, Cryan JF4.