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Conférence mensuelle - Christian LuscherThe emergence of a circuit model for addiction: from synaptic mechanisms to therapeutic potential

Abstract :

We will review the synaptic mechanisms that underlie the behavioral adaptations in drug addiction. Several forms of “drug-evoked synaptic plasticity” have been observed and links of causalities to addiction symptoms in rodent models were established. We will review experiment showing that normalizing synaptic transmission in vivo with optogenetic approaches can erase pathological behavior. In the last part we will develop translational protocols to emulate optogenetic protocols with deep brain stimulation, which may lead to clinical studies in the future. 

 

Selected publications

Convergence of Reinforcing and Anhedonic Cocaine Effects in the Ventral Pallidum. Creed M, Ntamati NR, Chandra R, Lobo MK, Lüscher C. Neuron. 2016 Oct 5;92(1):214-226. doi: 10.1016/j.neuron.2016.09.001.

 The Emergence of a Circuit Model for Addiction. Lüscher C. Annu Rev Neurosci. 2016 Jul 8;39:257-76. doi: 10.1146/annurev-neuro-070815-013920.

 Sufficiency of Mesolimbic Dopamine Neuron Stimulation for the Progression to Addiction. Pascoli V, Terrier J, Hiver A, Lüscher C. Neuron. 2015 Dec 2;88(5):1054-66. doi: 10.1016/j.neuron.2015.10.017.

Scientific focus :

Christian Lüscher is a professor of Neuroscience at the University of Geneva and an attending in Neurology at the University Hospital of Geneva. 

He obtained his medical degree from the Universities of Lausanne and Berne. After a residency in Neurology he spent three years at UC San Francisco to study synaptic plasticity. He established his own laboratory at the University of Geneva in 1999 with a career award of the Swiss NSF and became full professor in 2009. 

Christian Lüscher has received several awards, including an ERC advanced grant, as well as the Bing, Cloëtta, Ott and Koetzer Prizes. He is an editor for eNeuro and Science. 

PhD series



La Fédération Bordeaux Neurocampus, en concertation avec l'Ecole Doctorale SVS, met en place une série de conférences destinée
 à l'ensemble des étudiants effectuant leur thèse dans les laboratoires de neurosciences de Bordeaux Neurocampus. 
Les doctorants Neuroscience in Bordeaux Association (NBA) sont chargés de l'organisation. 

Modalités : tous les premiers vendredi de chaque mois à 11h30 (durée : 1h), puis pizzas avec les étudiants et rencontres avec les personnes intéressées l'après-midi

If you are interested to share pizzas and a good moment with her (12h30 - 14h), please register on this Doodle... 
(maximum 15 people, first-come-first-served!)