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Séminaire impromptu - Arianna Rinaldi / séminaire annulé !Stress-associated individual variability in microRNAs expression in the prefrontal cortex

Abstract :


 When confronting with stress, most individuals are resilient to its deleterious effects while a minor population develops long-lasting reactions. The molecular mechanisms of such divergent behavioral response to stress remain unclear. We examined the expression of miRNAs, key modulators of gene expression, in the prefrontal cortex (PFC) of a mouse model of traumatic stress, with the aim to identify and further characterize miRNAs potentially involved in stress vulnerability.

Arianna Rinaldi has recently joined the Department of Biology and Biotechnology at Sapienza University of Rome, after spending many years as a postdoc in the laboratory of Dr. Matt Nolan at the University of Edinburgh. She is interested in understanding the mechanisms of memory encoding and storage in neural circuits, using a broad variety of approaches, ranging from molecular and imaging techniques to in vitro electrophysiology and behavioral analysis.

Selected publications

A.Rinaldi, S.Vincenti, F.De Vito, I.Bozzoni, A.Oliverio, C.Presutti, P.Fragapane, A.Mele (2010). Stress induces region specific alterations in microRNAs expression in mice. Behavioural Brain Research, 208: 265-269.

 A.Rinaldi, C.Defterali, A.Mialot, D.L.F.Garden, M.Beraneck, M.F.Nolan (2013). Specific contribution of HCN1 channels in Purkinje cells to motor learning and synaptic integration. Journal of Physiology, 591: 5691-5709.

 C.Mannironi, A.Biundo, S.Rajendran, F.De Vito, S.Caioli, C.Zona, T.Ciotti, S.Caristi, E.Perlas, I.Bozzoni, A.Rinaldi, A.Mele, C.Presutti (2017). miR-135a regulates synaptic activity and anxiety-like behavior in amygdala. Molecular  Neurobiology, doi: 10.1007/s12035-017-0564-9 (In Press).