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Séminaire - Antoine AdamantidisThalamic relay supports onset, synchrony and travelling of cortical UP-states during sleep

Abstract :

 During mammalian non-rapid eye movement sleep (NREMS), cortical activity is characterised by slow wave oscillations (1-4 Hz) resulting from large neuronal ensembles alternating between active (UP) and quiescent (DOWN) states. However, the circuit mechanism underlying the onset, synchrony and travelling of cortical UP-states remains unclear.

Here, we show that spiking activity of centromedial thalamus (CMT) neurones is phase-advanced to cingulate cortex UP-states during sleep, as compared to other midline and sensory thalamic neurones (VB), and predicts NREMS-to-Wake transitions. Accordingly, optogenetic activation of CMT, but not VB, neurones during NREMS induces rapid awakening through initiation of synchronous UP-states in the cingulate cortex. Importantly, the travelling of these frontally-generated UP-states across the neocortex depends on antero-dorsal (AD) thalamic relay cells.
These results demonstrate that CMT and AD neurones initiate and synchronise, respectively, cortical UP-states over large-scale cortical circuits, essential to NREMS stability and sleep homeostasis.

Selected publications

Causal evidence for the role of REM sleep theta rhythm in contextual memory consolidation
Richard Boyce, Stephen D. Glasgow, Sylvain Williams, Antoine Adamantidis,
Science 13 May 2016:Vol. 352, Issue 6287, pp. 812-816, DOI: 10.1126/science.aad5252

Role of REM Sleep, Melanin Concentrating Hormone and Orexin/Hypocretin Systems in the Sleep Deprivation Pre-Ischemia. Pace M, Adamantidis A, Facchin L, Bassetti C. PLoS One. 2017 Jan 6;12(1):e0168430. doi: 10.1371/journal.pone.0168430. eCollection 2017.

REM Sleep on It!Boyce R, Adamantidis A.Neuropsychopharmacology. 2017 Jan;42(1):375. doi: 10.1038/npp.2016.227. No abstract available.

Sleep & metabolism: The multitasking ability of lateral hypothalamic inhibitory circuitries.Herrera CG, Ponomarenko A, Korotkova T, Burdakov D, Adamantidis A.Front Neuroendocrinol. 2017 Jan;44:27-34. doi: 10.1016/j.yfrne.2016.11.002. Epub 2016 Nov 21. Review.

Monoaminergic control of brain states and sensory processing: Existing knowledge and recent insights obtained with optogenetics. Lőrincz ML, Adamantidis AR.Prog Neurobiol. 2017 Apr;151:237-253. doi: 10.1016/j.pneurobio.2016.09.003. Epub 2016 Sep 12. Review.

Scientific focus :

Antoine Adamantidis, PhD, is investigating the functional wiring and dynamics of neural circuits controlling sleep and wake states. He is using a combination of state-of-the-art molecular, cellular and behavioural technologies, which include genetic mouse engineering, in vitro and in vivo electrophysiology, behavioural paradigms and the emerging field of optogenetics. Optogenetics combines optical and genetic methodologies to modulate the activity of neural circuitry at very high speed, in order to understand how information is processed in the brain.

His research findings may lead to a better understanding of how the brain controls sleep, attention and cognition. This may open new therapeutic strategies for the treatment of sleep disorders and neuropsychiatric illnesses associated with sleep disturbances.