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Séminaire - Thomas BiedererHow to build a synapse: Trans-synaptic interactions instruct synaptogenesis

Abstract :

Visiting Scholars/ Expert des protéines d'adhérence synaptiques (SynCAM).

 Dr. Thomas Biederer received a Ph.D. in Cell Biology from the Humboldt-Universität zu Berlin, Germany. Dr. Biederer then pursued postdoctoral training with Dr. Thomas Südhof at the UT Southwestern Medical Center at Dallas to investigate mechanisms of synapse formation. He became faculty member at Yale University in 2003, and joined in 2013 the Tufts University Medical School, where he is Associate Professor in the Department of Neuroscience.

 Dr. Biederer’s multidisciplinary program is motivated by his interests in synaptic biology and the profound disease relevance of synaptic aberrations. His focus lies on the organization of excitatory synapses by adhesive interactions across the synaptic cleft. On a molecular level, Dr. Biederer analyzes the signaling pathways driving synapse formation and the functional cooperation of trans-synaptic interactions. He complements this with studying the formation of synaptic connections and the activity-dependent wiring of neuronal networks in vivo, using transgenic and knock-out mouse models.

Selected publications

Perez de Arce, K., Schrod, N., Metzbower, S. W. R., Allgeyer, E., Kong, G. K.-W., Tang, A., Krupp, A.J., Stein, V., Liu, X., Bewersdorf, J., Blanpied, T., Lucic, V., and Biederer, T. (2015) Topographic mapping of the synaptic cleft into adhesive nanodomains. Neuron 88:1165–1172.

Cheadle, L. and Biederer, T. (2014) Activity-dependent regulation of dendritic complexity by Semaphorin 3A through Farp1. Journal of Neuroscience 34:7999-8009.

Cheadle, L. and Biederer, T. (2012) The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and trans-synaptic organization. Journal of Cell Biology 199:985-1001.

Fogel, A.I., Stagi, M., Perez de Arce, K. and Biederer, T. (2011) Lateral assembly of the immunoglobulin protein SynCAM 1 controls its adhesive function and instructs synapse formation. EMBO Journal 30: 4728-4738.

Robbins, E.M., Krupp, A.J., Perez de Arce, K., Ghosh, A., Fogel. A.I., Boucard, A., Südhof, T.C., Stein, V., Biederer, T. (2010) SynCAM 1 adhesion dynamically regulates synapse number and impacts plasticity and learning. Neuron 68: 894-906.

Stagi, M., Fogel, A.I. and Biederer, T. (2010) SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones. Proceedings of the National Academy of Sciences USA 107: 7568-7573.