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Séminaire impromptu - Terry HébertNuclear G proteins in cardiac transcriptional regulation

Abstract :


 Research in my lab is centered broadly around the theme of G protein-coupled signal transduction systems.
These signalling systems are activated by agonists that bind to G protein-coupled receptors (GPCRs) leading to the regulation of effector proteins (e.g. enzymes and ion channels) by a transducer.
We are interested in
1) basic mechanisms of how these signalling systems are wired,
2) novel signalling complexes and pathways associated with alternative subcellular localization of GPCRs and
3) the roles that these architectural features of signalling complex design might play in cardiac disease with a particular emphasis on congenital heart disease. More recently, my group has also become interested in how novel allosteric regulators of these receptors might be developed and tested, here with a focus on inflammatory mediators, their receptors and their roles in health and disease. All of the projects are currently funded by CIHR, the first three by individual grants as PI and the latter as part of a CIHR Team in GPCR allosteric regulation.