Séminaire - Scott SternsonChemogenetic ion channel tools for neurobiology8 juil. 2016 à 14:00 (Salle de conf Institut Magendie)
Neuron activity is dependent on the concerted action of ion channels. Several years ago, we combined synthetic chemistry with protein engineering of ligand gated ion channel to develop pharmacologically selective ion channels with diverse conductance properties. These tools can be used to powerfully activate or inhibit neurons. I will discuss these engineered ligand gated ion channels and recent advances that we have made for their use in vivo.
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