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Séminaire - Markus FendtNeurobiology of innate and learned fear

Abstract :

Potentially dangerous stimuli induce the emotion fear in humans and animals. Fear consists of behavioral and autonomic changes that ultimately support the survival of humans and animals in threatening situations. Notably, different neuropsychiatric disorders in humans such as depression or anxiety disorders are connected to pathologically increased fear.

Our research goal is to understand the mechanisms underlying innate and learned fear. To this aim, we are using several behavioral paradigms in laboratory rodents combined pharmacological, genetic, electrophysiological, imaging and histological methods

Selected publications

Wernecke KEA, Vincenz D, Storsberg S, D’Hanis W, Goldschmidt J & Fendt M (2015) Fox urine exposure induces avoidance behavior in rats and activates the amygdalar olfactory cortex. Behav Brain Res 279: 76-81. DOI: 10.1016/j.bbr.2014.11.020

Gerber B, Yarali A, Diegelmann S, Wotjak CT, Pauli P & Fendt M (2014) Pain-relief learning in flies, rats, and man: Basic research and applied perspectives. Learn Mem 21: 232-252

Fendt M, Imobersteg S, Peterlik D, Chaperon F, Mattes C, Wittmann C, Olpe HR, Mosbacher J, Vranesic I, van der Putten H, McAllister KH, Flor PJ & Gee CE (2013) Differential roles of mGlu7 and mGlu8 in amygdala-dependent behavior and physiology. Neuropharmacology 72: 215-223.

Ferrero DM, Lemon JK, Flügge D, Pashkovski SL, Korzan WJ, Datta SR, Spehr M, Fendt M & Liberles SD (2011) Detection and avoidance of a carnivore odor by prey. Proc Natl Acad Sci USA 108: 11235-11240.