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Séminaire impromptu - Felipe A. CourtVesicular-mediated RNA transfer in the nervous system

Abstract :


 Felipe Court studied biology in Chile working as an undergraduate in the lab of Dr. Jaime Alvarez
in local protein synthesis in axons. Then he moved to Europe and obtained an MSc and later a Ph.D. at Edinburgh University working in the labs of Dr. Richard Ribchester and Dr. Peter Brophy in demyelinating conditions of the peripheral nervous system. Holding an EMBO postdoctoral fellowship, he moved to the lab of Dr. Laura Feltri in Milano, Italy.

Dr. Court research has been focused in studying the relationship between glial cells and neurons in different biological processes, including axonal degeneration, regeneration and intracellular transfer of cargoes. To this end, his lab uses models of axonal degeneration and regeneration in vivo and in vitro.

Selected publications

Maritza Oñate, Alejandra Catenaccio, Gabriela Martínez, Donna Armentano, Geoffrey Parsons, Bredford Kerr, Claudio Hetz & Felipe A. Court (2016) Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury. Scientific Reports, Article number: 21709.

Villegas R, Martinez NW, Lillo J, Pihan P, Hernandez D, Twiss JL, Court FA (2014) Calcium Release from Intra-Axonal Endoplasmic Reticulum Leads to Axon Degeneration through Mitochondrial Dysfunction. J Neurosci. 34(21):7179-89.

Lopez-Verrilli MA, Picou, F, Court FA*. Schwann cell-derived exosomes enhance axonal regeneration in the peripheral nervous system. GLIA. 61(11):1795-806

Calixto A. Jara J.S., Court F.A (2012). Diapause formation and downregulation of Insulin-like signaling via DAF-16/FOXO delays axonal degeneration and neuronal loss. PloS Genetics. PLoS Genet 8(12): e1003141.

Court FA*, Coleman MP* (2012) Mitochondria as a central sensor for axonal degenerative stimuli. Trends Neurosci. 35(6):364-72.

Court FA, Hendriks WT, MacGillavry HD, Alvarez J, van Minnen J (2008) Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system. J Neurosci 28:11024-11029.

Court FA, Sherman DL, Pratt T, Garry EM, Ribchester RR, Cottrell DF, Fleetwood-Walker SM, Brophy PJ (2004) Restricted growth of Schwann cells lacking Cajal bands slows conduction in myelinated nerves. Nature 431:191-195.

David Perrais, PhD, CNRS. Team: Dynamics of synapse organization and function. david.perrais(at)u-bordeaux.fr