Séminaire - Liset Menendez de la PridaActivity pattern of hippocampal circuits17 juin 2016 à 11:30 (Magendie)
Interaction between brain oscillators is as a critical mechanism to orchestrate synchronization between neuronal circuits at different scales. Hippocampal microcircuits are especially suitable to better understand how this mechanism operates in health and disease. In this talk, I will review recent finding from my lab on the microcircuit structure of a range of natural hippocampal oscillations and their distortion in temporal lobe epilepsy, a disease affecting the structure especifically.
We will discuss how a range of hippocampal oscillations emerge from basic rules governing the operation of these circuits using a combination of single-cell and population recordings, and relate their distortion to different cognitive co-morbidities of TLE.
1: Valero M, Cid E, Averkin RG, Aguilar J, Sanchez-Aguilera A, Viney TJ,
Gomez-Dominguez D, Bellistri E, de la Prida LM. Determinants of different deepand superficial CA1 pyramidal cell dynamics during sharp-wave ripples. Nat Neurosci. 2015 Sep;18(9):1281-90.
2: Inostroza M, Brotons-Mas JR, Laurent F, Cid E, de la Prida LM. Specific
impairment of "what-where-when" episodic-like memory in experimental models of temporal lobe epilepsy. J Neurosci. 2013 Nov 6;33(45):17749-62.
3: Huberfeld G, Menendez de la Prida L, Pallud J, Cohen I, Le Van QuyenM, Adam C, Clemenceau S, Baulac M, Miles R. Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy. Nat Neurosci. 2011May;14(5):627-34.