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Séminaire - Yves de KoninckChloride dynamics: a fragile equilibrium at the heart of several brain disorders

Abstract :

Conférence exceptionnellement  déplacée le Jeudi 30 Juin à la place du vendredi 1er Juillet cause FENS.  

Fast synaptic inhibition relies on tight regulation of intracellular chloride. Chloride dysregulation is implicated in several neurological and psychiatric disorders. Beyond mere disinhibition, the consequences of chloride dysregulation are multifaceted and best understood in terms of a dynamical system involving complex interactions between multiple processes operating on many spatiotemporal scales.
This dynamical perspective helps explain many unintuitive manifestations of chloride dysregulation. I will discuss how taking into account the dynamics and regulation of intracellular chloride is important for understanding how synaptic inhibition fails, how to best detect that failure, why chloride regulation is so important for information coding, and the overall consequences one can derive for therapeutics.


Selected publications

"A spinal analog of memory reconsolidation enables reversal of hyperalgesia." , Bonin RP, De Koninck Y. , Nat Neurosci. 2014 Jul 6. (2014)

"KCC2: a new therapeutical target for the treatment of neurological diseases (article in French)." , Bergeron MJ, Castonguay A, De Koninck Y. , Med Sci (Paris). 2014 May;30(5):514-7. (2014)

"Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABAA Receptors." , Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, Ribeiro-da-Silva A, De Koninck Y. , J Neurosci. 2014 Jun 11;34(24):8300-17. (2014)

"Extended two-photon microscopy in live samples with Bessel beams: steadier focus, faster volume scans, and simpler stereoscopic imaging." ,

Thériault G, Cottet M, Castonguay A, McCarthy N, De Koninck Y.
, Front Cell Neurosci. 2014 May 20;8:139. (2014)

A simplified up-down method (SUDO) for measuring mechanical nociception in rodents using von Frey filaments. Bonin RP, Bories C, De Koninck Y. , Mol Pain. 2014 Apr 16;10(1):26. (2014)