Aller au contenuAller au menuAller à la recherche

Séminaire - David RobbeThe striatum contribution to action monitoring and control

Abstract :

 The wide majority of  textbooks and articles on the striatum starts with a sentence resembling to: “the striatum is critical for the control of actions”. But what does this mean exactly? Does the striatum store action representations and  generate actions on its own? Does the striatum function like a traffic light that sends start or stop signals outside the basal ganglia (e.g., to the primary motor cortex) to trigger or block the execution of motor programs according to a given behavioral context? Is the striatum more generally concerned with modulating the vigor of actions, which would explain bradykinesia in Parkinson's disease patients and animals models? Or does the striatum is more concerned with learning new actions rather than executing those that are already learned? For each of these questions, there is no clear definitive answer.

During my presentation, I will present resultsfromelectrophysiological and perturbation experimentsin rodents performing new motor tasks.  These results suggest that the striatumbasic function is towork as a “super  integrator” that continuously monitor actions execution. We hypothesize that this monitoring function is crucial both for learning new motor sequences and constraining the execution of previously well-learned actions such as habits.

Selected publications

The striatum multiplexes contextual and kinematic information to constrain motor habits execution.
Rueda-Orozco PE, Robbe D - Nature neuroscience - Jan 2015

Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony.
Sales-Carbonell C, Rueda-Orozco PE, Soria-Gómez E, Buzsáki G, Marsicano G, Robbe D - Proceedings of the National Academy of Sciences of the United States of America - Jan 2013

Locomotion-related oscillatory body movements at 6-12 Hz modulate the hippocampal theta rhythm.
Ledberg A, Robbe D - PloS one - Jan 2011