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Séminaire - Daniele Caprioli Neuronal mechanisms of incubation of methamphetamine craving after prolonged voluntary abstinence

Abstract :

Methamphetamine addiction is characterized by high relapse rates often precipitated by exposure to drug-associated cues that provoke drug craving. In rodent studies of drug craving, cue-induced drug seeking is assessed after experimenter-imposed forced abstinence. However, in humans, abstinence is often self-imposed, or voluntary, in favor of other non-addictive alternative rewards. In the present lecture I will present a new choice-based rat model of relapse, along with its first  neurobehavioral characterization, in which Meth craving is observed after prolonged voluntary abstinence.

Selected publications

Belin, D., Belin-Rauscent, A., Daniel. M. L., Puaud, M., Jupp, B., Sawiak, S. J., Howett, D., McKenzie, C., Besson, Caprioli, D., M., Robbins, T. W., Everitt, B. J., Dalley, J. W. (2015). From impulses to maladaptive actions: the insula is a neurobiological gate for the development of compulsive behavior. Mol Psychiatry, doi: 10.1038/mp.2015.140.


Caprioli, D., Venniro, M., Zeric, T., Li, X., Adhikary, S., Madangopal, R., Marchant, N. J., Lucantonio, F., Schoenbaum, G., Bossert, J. M., Shaham, Y. (2015). Effect of the Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor 2 AZD8529 on Incubation of Methamphetamine Craving After Prolonged Voluntary Abstinence in a Rat Model. Biol Psychiatry, 78(7), 463-473. doi: 10.1016/j.biopsych.2015.02.018


Caprioli, D., Jupp, B., Hong, Y. T., Sawiak, S. J., Ferrari, V., Wharton, L., Williamson, D. J., McNabb, C., Berry, D., Aigbirhio, F. I., Robbins, T. W., Fryer, T. D., Dalley, J. W. (2015). Dissociable rate-dependent effects of oral methylphenidate on impulsivity and D2/3 receptor availability in the striatum. J Neurosci, 35(9), 3747-3755. doi: 10.1523/JNEUROSCI.3890-14.2015


Caprioli, D., Zeric, T., Thorndike, E. B., Venniro, M. (2015). Persistent palatable food preference in rats with a history of limited and extended access to methamphetamine self-administration. Addict Biol, 20(5), 913-926. doi: 10.1111/adb.12220


Caprioli, D., Sawiak, S. J., Merlo, E., Theobald, D. E., Spoelder, M., Jupp, B., Voon, V., Carpenter, T. A., Everitt, B. J., Robbins, T. W., Dalley, J. W. (2014). Gamma aminobutyric acidergic and neuronal structural markers in the nucleus accumbens core underlie trait-like impulsive behavior. Biol Psychiatry, 75(2), 115-123. doi: 10.1016/j.biopsych.2013.07.013


Caprioli, D., Hong, Y. T., Sawiak, S. J., Ferrari, V., Williamson, D. J., Jupp, B., Adrian Carpenter, T., Aigbirhio, F. I., Everitt, B. J., Robbins, T. W., Fryer, T. D., Dalley, J. W. (2013). Baseline-dependent effects of cocaine pre-exposure on impulsivity and D2/3 receptor availability in the rat striatum: possible relevance to the attention-deficit hyperactivity syndrome. Neuropsychopharmacology, 38(8), 1460-1471. doi: 10.1038/npp.2013.44


Jupp, B., Caprioli, D., Saigal, N., Reverte, I., Shrestha, S., Cumming, P., Everitt, B. J., Robbins, T. W., Dalley, J. W. (2013). Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex. Eur J Neurosci, 37(9), 1519-1528. doi: 10.1111/ejn.12146


Caprioli, D., Celentano, M., Dubla, A., Lucantonio, F., Nencini, P., Badiani, A. (2009). Ambience and drug choice: cocaine- and heroin-taking as a function of environmental context in humans and rats. Biol Psychiatry, 65(10), 893-899. doi: 10.1016/j.biopsych.2008.12.009