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Séminaire - Alessandro TrevesMemory and representations of space: CA3 and mEC.

Abstract :

Professor of "the Neural Basis of Cognition"

Recent studies have highlighted many differences between CA3 place cells andgrid cells, from their spatial information content to their flexibility. One should remember, however, that the latter have been studied in flat arenas,quite dissimilar from ecological rodent environments, which typically present a Gaussian curvature. Acquiring grid representations of curved space implies that phase relations cannot be preserved, and hence small fragments have to be memorized separately. I show how to estimate the number of fragments that can be separately stored and retrieved, i.e. the memory capacity of the entorhinal network. This sheds I propose new light on the CA3-mEC duality.

Selected publications

Alessandro Treves, Ayumu Tashiro, Menno P Witter, and Edvard I Moser. What is the mammalian dentate gyrus good for Neuroscience?  154:1155­72, 2008. doi:10.1016/j.neuroscience.2008.04.073

Erika Cerasti and Alessandro Treves. The spatial representations acquired in CA3 by self-organizing recurrent connections. Frontiers in Cellular Neuroscience, 7:Article 112, 2013

Charlotte B Alme, Chenglin Miao, Karel Jezek, Alessandro Treves, Edvard I Moser, and May-Britt Moser. Place cells in the hippocampus: Eleven maps for eleven rooms. Proceedings of the National Academy of Sciences of the USA, 111:18428­18435, 2014

Eugenio Urdapilleta, Francesca Troiani, Federico Stella, and Alessandro Treves. Can rodents conceive hyperbolic spaces? Journal of The Royal Society Interface, 12:20141214, 2015