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Séminaire impromptu - Yavin Shaham & Danai RigaContext-induced relapse to drug seeking: mechanisms and new models & The deeper the blues, the greater the booze?

Abstract :

Séminaires entre 11h et 12h30

Context-induced relapse to drug seeking: mechanisms and new models.

Yavin Shaham (NIH/NIDA/IRP, Baltimore) received his BS in 1986 and his MA in 1988 from the Hebrew U, Jerusalem. He then received his PhD in 1992 from the Uniformed Services University of the Health Sciences, Bethesda. His postdoctoral training from 1992 to 1995 was at Concordia U, Montreal, in the laboratory of Dr. Jane Stewart.  From 1996 to 1998 he was an investigator at the Addiction Research Center in Toronto. He joined NIDA intramural program in 1998 where he is currently a tenured Branch Chief and a Senior Investigator. In 2001 he received the NIDA Director’s Award of Merit and in 2006 he received the Society of Neuroscience Jacob Waletzky award for innovative research in drug and alcohol addiction. He has published over 140 empirical papers, reviews, and commentaries, and his papers were cited over 10,500 times. He currently serves as a Senior Editor for The Journal of Neuroscience. He is also an editorial board member of Biological Psychiatry, Neuropsychopharmacology, Psychopharmacology, and Addiction Biology. His group investigates mechanisms of relapse to heroin, alcohol, methamphetamine, and palatable food, as assessed in rat models developed in his lab.


Recent empirical papers
Bossert JM, Stern AL, Theberge F, Koya E, Hope BT, Shaham Y (2011) Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin. Nature Neuroscience 14:420-422

Xue YX, Luo YX, Wu P, Shi HS, Xue LF, Chen C, Zhu WL, Ding ZB, Shi J, Epstein DH, Shaham Y, Lu L (2012) A memory retrieval-extinction procedure to prevent drug craving and relapse. Science 336:241-245

Bossert JM, Stern AL, Theberge FR, Marchant MJ, Wang HL, Morales M, Shaham Y (2012) Role of projections from ventral medial prefrontal cortex to nucleus accumbens shell in context-induced reinstatement of heroin seeking. The Journal of Neuroscience 32:4982-4991

Cifani C, Koya E, Navarre BM, Calu DJ, Baumann MH, Marchant MJ, Liu QR, Khuc T, Pickel J, Lupica CR, Shaham Y, Hope BT (2012) Medial prefrontal cortex neuronal activation and synaptic alterations after stress-induced reinstatement of palatable food seeking: a study using c-fos-GFP transgenic female rats. The Journal of Neuroscience 32:8480–8490


Abstract from Danai Riga

The deeper the blues, the greater the booze?

The risk of alcohol dependence in individuals suffering from Major Depression is twice as high when compared to the general population. By combining the social defeat-induced persistent stress paradigm with chronic alcohol self-administration, we previously introduced a preclinical model that links a sustained depressive-like state with increased alcohol-seeking and -taking behavior in Wistar rats. Currently, we are investigating the effects of individual variability in depressive-like state on initiation, maintenance and relapse of alcohol-seeking. Our results indicate that depression-susceptibility predicts subsequent vulnerability to alcohol dependence, questioning a common underlying neuronal substrate. Our long-term aim is to identify molecular substrates that could target concurrent depression and alcohol dependence.

 This seminar wil be held around 12h

Recent publications
Riga D, Schmitz LJM, van der Harst JE, van Mourik Y, Hoogendijk WJG, Smit AB, De Vries TJ, Spijker S. A sustained depressive state promotes a guanfacine reversible susceptibility to alcohol seeking in rats. Neuropsychopharmacology, under review.

Van Bokhoven P, Oomen CA, Hoogendijk WJ, Smit AB, Lucassen PJ, Spijker S. (2011). Reduction in hippocampal neurogenesis after social defeat is long-lasting and responsive to late antidepressant treatment. Eur J Neurosci., 2

Wouda JA, Riga D, De Vries W, Stegeman M, van Mourik Y, Schetters D, Schoffelmeer AN, Pattij T, De Vries TJ. Varenicline attenuates cue-induced relapse to alcohol, but not nicotine seeking, while reducing inhibitory response control. Psychopharmacology (Berl). 2011, 216(2): 267-77. 

Scientific Focus
The Spijker lab focuses on molecular and cellular plasticity mechanisms in rat and mouse models of human psychiatric disease. My personal interest lies in understanding the molecular substrates governing pathological states associated with reward, such as depressive and substance abuse disorders. My efforts have been focused on testing hypotheses with possible clinical implications, aiming to identify molecular targets that might be of proven therapeutic value against drug dependence, depression and their comorbidity. Essential to this aim is to thoroughly understand the substrate of aberrant synaptic plasticity, as well as the forces that govern long-term neuroadaptations underlying dysfunctional reward processes that lead to disease.