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Séminaire impromptu - Christophe MagnanBrain lipid sensing and nervous control of energy balance

Abstract :

Fatty acid (FA) sensitive neurons are present in many sites throughout the brain, including the hypothalamus and brainstem, and play a key role in the neural control of energy and glucose homeostasis. Through neuronal output, FA sensing modulate feeding behaviour as well as both insulin secretion and action.  This suggests that daily variations in plasma FA concentrations might be detected by the central nervous system as a signal which contributes to the regulation of energy balance.

Finally, local hydrolysis of triglycerides by lipoprotein lipase expressed in specific brain areas (hypothalamus / hippocampus) may also contribute to control of energy balance by providing FA in these sensitive neurons. Besides these physiological effects, FA overload or metabolic dysfunction might impair neural control of energy homeostasis and contribute to obesity and/or type 2 diabetes in predisposed subjects.

Selected publications

Metabolic sensing and the brain: who, what, where, and how? Levin BE, Magnan C, Dunn-Meynell A, Le Foll C. Endocrinology. 2011 Jul;152(7):2552-7. doi: 10.1210/en.2011-0194. Epub 2011 Apr 26. Review.

Brain lipid sensing and nervous control of energy balance. Migrenne S, Le Foll C, Levin BE, Magnan C. Diabetes Metab. 2011 Apr;37(2):83-8.

Sensing the fuels: glucose and lipid signaling in the CNS controlling energy homeostasis. Jordan SD, Könner AC, Brüning JC. Cell Mol Life Sci. 2010 Oct;67(19):3255-73.

Guillaume Ferreira (guillaume.ferreira @

To eat or not to eat ?

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to eat or not to eat.....

Responsable de l'équipe de recherche: HERGE (Homéostasie Energétique et Régulation nerveuse et Endocrine)Unité de recherche : : CNRS EAC4413 BFA (Biologie Fonctionnelle et Adaptative)Université Paris Descartes