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Symposium - Alan Basbaum / Rolf-Detlef TreedeSymposium Fidex NeuroBIM & Réseau Inserm "Recherche sur la Douleur"

Abstract :

Des invitations de Daniel Voisin et Marc Landry

Vendredi 22 mars , Séminaires dans le cadre du Symposium "Fidex NeuroBIM" en association avec le Réseau Inserm de Recherche sur la Douleur. Conférences  prévue Amphi 5 à 11h30 pour Allan Basbaum .  et 14h pour Rolf-Detlef Treede

"Cellular and molecular mechanisms of pain and pain control"  Allan Basbaum, UCSF

Allan I. Basbaum, PhD, FRS is professor and chairman of the Department of Anatomy at the University of California, San Francisco (UCSF), and holds a joint appointment in the Department of Physiology. He is also a member of the W. M. Keck Foundation Center for Integrative Neuroscience. Dr. Basbaum’s interest in pain research began as an undergraduate at McGill University, in Montreal, where he worked with Ronald Melzack. After receiving a Ph.D from the University of Pennsylvania, he did postdoctoral research at University College London, with Patrick Wall. He then moved to UCSF and was appointed to the faculty in 1977.

Dr. Basbaum’s research concerns the transmission and control of pain messages, and the molecular mechanisms that underlie the development of persistent pain after tissue or nerve injury. He has served on the Council of the International Association for the Study of Pain (IASP), as its treasurer, and editor-in-chief of Pain, the journal of the IASP. Dr. Basbaum was elected to the American Academy of Arts and Sciences, to the Institute of Medicine and the British Academy of Medical Science. He is also a Fellow of the American Association for the Advancement of Science and of the Royal Society in the United Kingdom.

The nervous system detects and interprets a wide range of thermal and mechanical stimuli, as well as environmental and endogenous chemical irritants. When intense, these stimuli generate acute pain, and in the setting of persistent injury, both peripheral and central nervous system components of the pain transmission pathway exhibit tremendous plasticity, enhancing pain signals and producing hypersensitivity. When plasticity facilitates protective reflexes, it can be beneficial, but when the changes persist, a chronic pain condition may result. Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain. Furthermore, recent work in Prof. Basbaum’s laboratory has shown that forebrain GABAergic neuron precursors can integrate into adult spinal cord and reduce injury-induced neuropathic pain.

 

Rolf-Detlef Treede, Heidelberg University.

Neuropathic pain: translational research and impact for patient care

Rolf-Detlef Treede is currently Professor of Neurophysiology at the Center for Biomedicine and Medical Technology Mannheim (CBTM) of the Ruprecht-Karls-University Heidelberg in Mannheim, Germany.

After obtaining his "Dr. med." degree from the University of Hamburg in 1981, he joined the Department of Physiology at the University Hospital Eppendorf in Hamburg, Germany, until 1988 and again from 1990 to 1992. From 1988 to 1990 he was a Visiting Scientist with the Department of Neurosurgery at the Johns Hopkins Medical Institutions, Baltimore, USA, and from 1992-2007 Professor of Neurophysiology at the Institute of Physiology and Pathophysiology of the Johannes Gutenberg University in Mainz, Germany.

His research addresses the mechanisms and treatment of neuropathic pain, the cortical representation of pain, peripheral nociceptive transduction mechanisms, pain assessment by quantitative sensory testing and clinical neurophysiology. His laboratory employs a broad range of techniques in cell cultures, animals and humans. He has contributed to the development of clinical laboratory tests such as Quantitative Sensory Testing. As former NeuPSIG chair, he was involved in international guidelines on assessment and treatment of neuropathic pain. As former president of the German pain society DGSS, he contributed to the introduction of a chronic pain code into the German ICD-10 and to mandatory teaching of pain medicine in medical schools. Professor Treede is currently president-elect of the International Association for the Study of Pain (IASP).

Scientific focus :



Daniel Voisin & Marc Landry (daniel.voisin @ inserm.fr)