Aller au contenuAller au menuAller à la recherche

Séminaire impromptu - Adrian PalaciosFrom Eye to the Brain: A natural rodent model to study neurodegeneration

Abstract :

We present in this seminar our recent studies on the visual and brain process in Octodon degus, a natural rodent model of neurodegeneration. The degus brain during aging accumulates the key hallmark of Alzheimer diseases (AD), which correlate with loss of cognitive functions. More recently we found that the degus retina also shows a degenerative process similar to AD and together with a deterioration of their visual function.

Selected publications

1. Braidy N, Muñoz P, Palacios AG, Castellano-Gonzalez G, Inestrosa NC, Chung RS, Sachdev P, Guillemin GJ. (2012). Recent Animal Models For Alzheimer’s Disease: Clinical Implications And Basic Research. Journal of Neural Transmission 119(2):173-195.

2. Vasquez JC, Palacios AG, Marre O, Berry II MJ, Cessac B. (2012). Gibbs distribution analysis of temporal correlation structure on multicell spike trains from retina ganglion cells. Journal of Physiology Paris. 106(3-4):120-7.

3. Huang S, Treviño M, He K, Ardiles A, Di Pasquale R, Guo Y, Palacios A, Huganir R and Kirkwood A. (2012) Pull-Push neuromodulation of LTP and LTD enables bidirectional experience-induced synaptic scaling in visual cortex. Neuron. 73(3):497-510.

4. Ardiles AO, Tapia-Rojas CC, Mandal M, Alexandre F, Kirkwood A, Inestrosa NC & Palacios AG. (2012) Post-synaptic dysfunction is associated with spatial and object recognition memory loss in a natural model of Alzheimer's disease. Proceeding National Academy of Science. 109 (34) 13835-13840.

5. Ardiles A, Ewer J, Acosta ML, Kirkwood A, Martinez A, Ebensperger LA, Bozinovic F, Lee T, Palacios AG. (2013). Octodon degus (Molina 1782): A model in comparative biology and biomedicine. Cold Spring Harbor Protocols. 4: 312-18.

6. Ocampo-GarcésA, Hernandez F, Palacios AG. (2013). REM sleep phase preference in the crepuscular Octodon degus assessed by selective REM sleep deprivation. Sleep. 36(8):1247-1256.

7. Lowe J, Chang YL, Ardiles AO, Lim JC, Grey AC, Robertson KM, Danesh-Meyer HV, Palacios AG, Acosta ML. (2013). Alzheimer's disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers. Alzheimer & Dementia. In press.

8. Escobar M.J., Palacios A.G. (2013). Beyond the retina neural coding: On Models and Neural Rehabilitation. Journal of Physiology-Paris SI: Neural Coding-Chile 2012 (in press). DOI: 10.1016/j.jphysparis.2013.08.002