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Torfi Sigurdsson

Abstract :

Schizophrenia is a debilitating psychiatric illness whose causes are poorly understood, although the evidence to date clearly implicates dysfunctional brain circuits. It is also well known that genetic mutations play a major role in the pathology of the disease, raising the question of how such mutations affect neural circuit function. I will discuss experiments that aim to address this question by recording neural activity from mice engineered to carry genetic
mutations that predispose to schizophrenia. The results of these experiments shed light on how such mutations may alter network function in the brain and thus impair cognition and behavior.

Selected publications

Selected Publications
A. Adikhari, T. Sigurdsson, M. Topiwala, and J.A. Gordon (2010). Cross-correlation of instantaneous amplitudes of field potential oscillations: a straightforward frequency-specific method to estimate the directionality and lag between brain areas. Journal of Neuroscience Methods
191(2): 191-200.
T. Sigurdsson, K.L. Stark, M. Karayiorgou, J.A.Gogos and J.A. Gordon (2010). Impaired Hippocampal-Prefrontal Synchrony in a Genetic Mouse Model of
Schizophrenia. Nature 464: 763-7.
T. Sigurdsson, C.K. Cain, V. Doyere and J.E. LeDoux (2010). Asymmetries in long-term and short-term plasticity at thalamic and cortical inputs to the amygdala in vivo. European Journal of Neuroscience 31(2): 250:262.
T. Sigurdsson, V. Doyere, C.K. Cain and J.E. LeDoux (2007). Long-term
potentiation in the amygdala: a cellular mechanism of fear learning and
memory. Neuropharmacology 52(1):215-22

Cyril Herry (cyril.herry @

Selected publications

Selected Publications
Self-monitoring of social facial expressions in the primate amygdala and cingulate cortex.Livneh U, Resnik J, Shohat Y, Paz R.Proc Natl Acad Sci U S A. 2012 Oct 29. [Epub ahead of print]

Dirnberger G, Hesselmann G, Roiser JP, Preminger S, Jahanshahi M, Paz R Give it Time: Neural Evidence For Distorted Time Perception and Enhanced Memory Encoding in Emotional Situations.
Neuroimage (2012) Html link to full text

Livneh U, Paz R
Aversive-Bias and Stage-Selectivity in Neurons of the Primate Amygdala During Acquisition, Extinction, and Overnight Retention.
Journal of Neuroscience (2012) Html link to full text