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Kobi Rosenblum

Abstract :

Very little is known about drugs which can enhance the consolidation phase of memories in the cortex, the brain structure considered to store at least partially, long term memories. We tested the hypothesis that pharmacological and genetic manipulation of translation machinery, known to be involved in the molecular consolidation phase, enhances positive or negative forms of cortical dependent taste memories. We found that dephosphorylation (Ser51) of eIF2α specifically in the cortex is both correlated and necessary for normal memory consolidation. In order to reduce eIF2α phosphorylation and improve memory consolidation, we pharmacologically inhibited the different eIF2α kinases. In addition, we tested the involvement of eIF2α and PKR in mice models of aging and sporadic Alzheimer disease.

Selected publications

Relevant recent publications:
Relevant recent publications:
1.Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjevi? K, Lacaille JC, Nader K, Sonenberg N (2007). eIF2α phosphorylation regulates the switch from short to long-term synaptic plasticity and memory. Cell 6;129(1):195-206. http://www.ncbi.nlm.nih.gov/pubmed/17418795
2. ApoE ε4 is associated with eIF2α phosphorylation and impaired learning in young mice (2013). Yifat Segev, Daniel M. Michaelson, Kobi Rosenblum Neurobiology of Aging.
http://www.ncbi.nlm.nih.gov/pubmed/22883908
3.Blocking eIF2a kinase – PKR – Enhances Positive and Negative Forms of Cortex-Dependent Taste Memory (2013). Stern Elad, Chinnakkaruppan Adaikkan, David Orit ,Sonenberg Nahum and Rosenblum Kobi. Journal of Neuroscience (in press).

Scientific focus :

Scientific Focus
We are interested in biological mechanisms of learning and memory. We aim to understand how memories are being formed and maintained and how memories are faded over time (forgetting).

We are using a combination of biological techniques including molecular biology, biochemistry, cellular imaging, electrophysiology, neuroanatomy and behavior in order to understand the molecular and cellular mechanisms of memory formation and consolidation. Recently, we found the involvement of specific proteins in memory consolidation (e.g. elongation factor-2 and MAPK). We try to understand the specific role of these proteins in learning processes. The research in the laboratory contributes to the growing understanding of how memories are being formed in the normal brain. In addition, the research may explain the biological mechanisms of memory and learning deficits in the case of aging and diseases.

Guillaume Ferreira (guillaume.ferreira @ bordeaux.inra.fr)