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Giorgio Carmignoto / annulé / reporté

Abstract :

Giorgio Carmignoto from the University of Padova (Italy)

Selected publications

New vistas on astroglia in convulsive and non-convulsive epilepsy highlight novel astrocytic targets for treatment. Crunelli V, Carmignoto G.
J Physiol. 2013 Feb 15;591(Pt 4):775-85. doi: 10.1113/jphysiol.2012.243378. Epub 2012 Dec 10.

Fast spiking interneuron control of seizure propagation in a cortical slice model of focal epilepsy. Cammarota M, Losi G, Chiavegato A, Zonta M, Carmignoto G.
J Physiol. 2013 Feb 15;591(Pt 4):807-22. doi: 10.1113/jphysiol.2012.238154. Epub 2012 Dec 3.

Computational model of neuron-astrocyte interactions during focal seizure generation.
Reato D, Cammarota M, Parra LC, Carmignoto G.
Front Comput Neurosci. 2012;6:81. doi: 10.3389/fncom.2012.00081. Epub 2012

Focus

Dr Giorgio Carmignoto is group leader at the Institute of Neuroscience which belongs to the National Research Council (CNR), the main public research organization in Italy. He is also associated with the Department of Experimental Biomedical Science of the University of Padova. The central theme of his research is the specific signalling between neurons and astrocytes investigated by laser-scanning microscope living cell imaging and patch-clamp recording techniques. Among obtained results are the first evidence for the ability of astrocytes i) to be activated by neurotransmitter synaptic release in slice preparations ; ii) to work as principal mediators of neurovascular coupling; iii) to generate neuronal synchrony by acting on extrasynaptic NMDA receptors. His research is now focused on the role of astrocytes in epilepsy.