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Séminaire - Ilya Rybak "CPG-based control respiration and locomotion"

Abstract :

Our long-term goal is to investigate and understand the key issue of neural control of movement: how different cellular, network and systems neural mechanisms are integrated across multiple levels of organization to produce motor behavior and to adapt this behavior to various external and internal conditions

Investigations of the brainstem neural mechanisms responsible for neural control of breathing and neural circuits in the spinal cord involved in control of locomotion provide a unique and attractive opportunity to develop and investigate comprehensive computational models that can bring into a uniform framework the existing experimental data and current hypotheses related to different levels of systems organization and behavior.
Our modeling studies are performed in close interactive collaboration with multiple leading experimental laboratories located in different universities, states and countries.

Selected publications

Effects of glycinergic inhibition failure on respiratory rhythm and pattern generation.
Shevtsova NA, Büsselberg D, Molkov YI, Bischoff AM, Smith JC, Richter DW, Rybak IA.
Prog Brain Res. 2014;209:25-38. doi: 10.1016/B978-0-444-63274-6.00002-3.
PMID: 24746041 [PubMed - in process] Free PMC Article

Rhythmic bursting in the pre-Bötzinger complex: mechanisms and models. Rybak IA, Molkov YI, Jasinski PE, Shevtsova NA, Smith JC. Prog Brain Res. 2014;209:1-23. doi: 10.1016/B978-0-444-63274-6.00001-1. PMID: 24746040 [PubMed - in process] Free PMC Article

Modelling genetic reorganization in the mouse spinal cord affecting left-right coordination during locomotion Rybak IA, Shevtsova NA, Kiehn O. J Physiol. 2013 Nov 15;591(Pt 22):5491-508. doi: 10.1113/jphysiol.2013.261115. Epub 2013 Sep 30. PMID: 24081162 [PubMed - indexed for MEDLINE]

Computational models and emergent properties of respiratory neural networks. Lindsey BG, Rybak IA, Smith JC. Compr Physiol. 2012 Jul;2(3):1619-70. Review. PMID: 23687564 [PubMed - indexed for MEDLINE] Free PMC Article

Activity-dependent changes in extracellular Ca2+ and K+ reveal pacemakers in the spinal locomotor-related network. Brocard F, Shevtsova NA, Bouhadfane M, Tazerart S, Heinemann U, Rybak IA, Vinay L. Neuron. 2013 Mar 20;77(6):1047-54. doi: 10.1016/j.neuron.2013.01.026. PMID: 23522041 [PubMed - indexed for MEDLINE] Free PMC Article

Scientific focus :

Research Goals

The long-term goal of Dr. Rybak's work is to understand the key issue of neural control of movement: how different cellular, network and systems' neural mechanisms are integrated across multiple levels of organization to produce motor behavior and to adapt this behavior to various external and internal conditions. Investigations of the brainstem neural mechanisms responsible for neural control of breathing, and neural circuits in the spinal cord involved in control of locomotion, provide a unique and attractive opportunity to develop and investigate comprehensive computational models that can bring into a uniform framework the existing experimental data and current hypotheses related to different levels of systems organization and behavior.