Aller au contenuAller au menuAller à la recherche

Séminaire impromptu - Alexei VerkhratskyIntroduction to glia

Abstract :


Dans le cadre du "M2S3 Neurosciences - Cellular and Molecular NeuroBiology", Alexei Verkhratsky présentera une conférence.

Prof. Alexei Verkhratsky is an internationally recognised scholar in the field of cellular neurophysiology.
His research is concentrated on the mechanisms of inter- and intracellular signalling in the CNS, being especially focused on two main types of neural cells, neurones and neuroglia. He made important contributions to understanding the chemical and electrical transmission in reciprocal neuronal-glial communications and on the role of intracellular Ca2+ signals in the integrative processes in the nervous system. Many of A. Verkhratsky’s studies are dedicated to investigations of cellular mechanisms of neurodegeneration. In recent years he studies the glial pathology in Alzheimer disease. He authored a pioneering hypothesis of astroglial atrophy as a mechanism of neurodegeneration. (Morgan & Claypool publishers)

Book review: “Glial physiology and pathophysiology” by Alexei Verkhratsky and Arthur Butt, Wiley-Blackwell, 2013 Front Syst Neurosci. 2014; 8: 17.Published online Feb 11, 2014. doi: 10.3389/fnsys.2014.00017  PMCID: PMC3920112



Horaires : 10h30-12h30

Lieu : Salle de conférence du Neurocentre Magendie

Selected publications

  • Lalo, U., Palygin, O., North, R., Verkhratsky, A. & Pankratov, Y (2011). Age-dependent remodelling of ionotropic signalling in cortical astroglia. Aging Cell, 10(3), 392-402. eScholarID:127249 | DOI:10.1111/j.1474-9726.2011.00682.x
  • Olabarria, M., Noristani, H., Verkhratsky, A. & Rodríguez, J (2010). Concomitant astroglial atrophy and astrogliosis in a triple transgenic animal model of Alzheimer's disease. Glia, 58(7), 831. eScholarID:91917 | PMID:20140958 | DOI:10.1002/glia.20967
  • Rodríguez JJ, Jones VC, Tabuchi M, Allan SM, Knight EM, LaFerla FM, Oddo S, Verkhratsky A. (2008). Impaired Adult Neurogenesis in the Dentate Gyrus of a Triple Transgenic Mouse Model of Alzheimer's Disease. PLoS ONE, 3(8), e2935. eScholarID:1c8224 | PMID:18698410 | DOI:10.1371/journal.pone.0002935
  • Lalo U, Pankratov Y, Wichert SP, Rossner MJ, North RA, Kirchhoff F, Verkhratsky A. (2008). P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. The Journal of neuroscience, 28(21), 5473-80. eScholarID:1c8251 | PMID:18495881 | DOI:10.1523/JNEUROSCI.1149-08.2008

Scientific focus :

Regulation of neuronal endoplasmic reticulum calcium stores by intraluminal calcium

In all eukaryotic cells there are two general mechanisms to generate a Ca2+ signal, that is either activation of Ca2+ entry through the cellular plasma membrane and/or the release of Ca2+ from specialised intracellular organelles (endoplasmic reticulum, in particular), generally known as intracellular calcium stores. Intracellular sources deliver most of the Ca2+ ions for the Ca2+ signal in non-excitable cells, as well as in several types of excitable cells (eg, muscle and secretory cells). Neurones are the notable exception, in which the plasmalemmal Ca2+ entry apparently dominates, with the intracellular calcium stores playing mostly a modulatory role. More

Aude Panatier (aude.panatier @ inserm.fr)