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Jeffrey H Kordower"A tale of two stories: why nigral neurons die in Parkinson's disease and how to save them"

Abstract :


Jeffrey Kordower is a leading researcher in the fields of gene therapy, neural transplantation, nonhuman primate models of neurodegenerative disease and experimental therapeutic strategies for Parkinson's and Huntington's disease.
In 1995, he made the pioneering demonstration that fetal transplants can survive in patients with Parkinson's disease; a paper that was published in The New England Journal of Medicine. In 2000, he published the lead article in Science, demonstrating for the first time that gene delivery of a trophic factor called GDNF can prevent degeneration and restore function in nonhuman primate models of Parkinson's disease. Dr. Kordower is a Scientific Advisory Board (SAB) Member for numerous biotechnology companies and foundations, including a founding member of the SAB for the Michael J. Fox Foundation. Currently his main interests involve gene therapy and cell replacement strategies using stem cells in rodent and nonhuman primate models of Parkinson's and Huntington's disease.

Selected publications

Merrill DA, Masliah E, Roberts JA, McKay H, Kordower JH, Mufson EJ, Tuszynski MH. Association of early experience with amyloid deposition in aged primates, Neurobiology of Aging, in press.
Kanaan N, Kordower JH, Collier TC. Age-related changes in glial cells of dopamine midbrain subregions in rhesus monkeys. Neurobiology of Aging, in press.
Dodiya H, Bjorklund T, Stansell J, Kirik D, Kordower JH. Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates, Molecular Therapy, in press.

Kinetic modelling and occupancy measures of the norepinephrine transporters in baboons using SPECT with (123) I-INER.
Tavares AA, Barret O, Batis J, Alagille D, Koren A, Papin C, Kudej G, Nice K, Kordower JH, Cosgrove KP, Kloczynski T, Brenner E, Seibyl J, Tamagnan G.
Synapse. 2012 Oct 8. doi: 10.1002/syn.21613. [Epub ahead of print]
Introduction: gene therapy has gone from a pipe dream to clinical reality.
Kordower JH, Kirik D.
Neurobiol Dis. 2012 Nov;48(2):151-2. Epub 2012 Jul 20. No abstract available.
Alterations in axonal transport motor proteins in sporadic and experimental Parkinson's disease.
Chu Y, Morfini GA, Langhamer LB, He Y, Brady ST, Kordower JH.
Brain. 2012 Jul;135(Pt 7):2058-73. Epub 2012 Jun 19.

Erwan Bézard et Pierre Philip