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Etienne Audinat"Role of microglia in the developing somatosensory "barrel" cortex"

Abstract :


Accumulative evidence indicates that microglial cells influence the normal development of brain synapses.
Yet, the mechanisms by which these immune cells target maturating synapses and influence their functional development at early postnatal stages remain poorly understood. Our recent work focuses on the roles of microglia in the whisker-related barrel field of the mouse somatosensory cortex during the first weeks of the postnatal development. In particular, we have analyzed the role of CX3CR1, a microglial receptor activated by the neuronal chemokine CX3CL1 (or fractalkine) and which controls key functions of microglial cells. I will present evidence indicating that the CX3CRL1/R1 signaling pathway is necessary for the recruitment of microglial cells at sites of thalamo-cortical synapses and for the normal functional maturation of these synapses.

Selected publications

Central Role of GABA in Neuron-Glia Interactions.
Vélez-Fort M, Audinat E, Angulo MC. Neuroscientist. 2012 Jun;18(3):237-50. Epub 2011 May 23.

Postnatal switch from synaptic to extrasynaptic transmission between interneurons and NG2 cells.
Vélez-Fort M, Maldonado PP, Butt AM, Audinat E, Angulo MC. J Neurosci. 2010 May 19;30(20):6921-9.

Predominant functional expression of Kv1.3 by activated microglia of the hippocampus after Status epilepticus.
Menteyne A, Levavasseur F, Audinat E, Avignone E. PLoS One. 2009 Aug 26;4(8):e6770.

Functional alpha 7-containing nicotinic receptors of NG2-expressing cells in the hippocampus. Vélez-Fort M, Audinat E, Angulo MC. Glia. 2009 Aug 1;57(10):1104-14.

GABA, a forgotten gliotransmitter. Angulo MC, Le Meur K, Kozlov AS, Charpak S, Audinat E. Prog Neurobiol. 2008 Nov;86(3):297-303. Epub 2008 Aug 20. Review.

Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling. Avignone E, Ulmann L, Levavasseur F, Rassendren F, Audinat E. J Neurosci. 2008 Sep 10;28(37):9133-44.

Elena Avignone