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William J Moody"Spontaneous waves of electrical activity in the developing mouse cerebral cortex: Developmental changes in wave propagation and pacemaker properties"

Abstract :


Spontaneous electrical activity is a central feature of the development of the central nervous system.
In mammals, this activity most often takes the form of waves of activity that propagate across large structures of the CNS. These waves occur in the absence of sensory input, but how they are initiated remains unclear. In the cerebral cortex, we have found that spontaneous waves of activity occur during a restricted period of development, from embryonic day 18 to postnatal day 10, and are initiated in the piriform cortex at all of these stages. At early stages of development, waves are restricted to the piriform cortex, but at later stages, they propagate dorsally past the rhinal fissure into the dorsal neocortex. Although the location of the pacemaker remains in the piriform cortex at all stages, the identity of the pacemaker neurons changes. Pharmacological evidence indicates that at early stages, the pacemaker is GABAergic. As development proceeds, however, glutamatergic neurons take over the pacemaker function. I will discuss the significance and possible mechanisms of this switch in pacemaker identity.        

Selected publications

Developmental changes in propagation patterns and transmitter dependence of waves of spontaneous activity in the mouse cerebral cortex.
Conhaim J, Easton CR, Becker MI, Barahimi M, Cedarbaum ER, Moore JG, Mather LF, Dabagh S, Minter DJ, Moen SP, Moody WJ.J Physiol. 2011 Mar 28. [Epub ahead of print]
Bimodal septal and cortical triggering and complex propagation patterns of spontaneous waves of activity in the developing mouse cerebral cortex.Conhaim J, Cedarbaum ER, Barahimi M, Moore JG, Becker MI, Gleiss H, Kohl C, Moody WJ.Dev Neurobiol. 2010 Sep;70(10):679-92.

Bilaterally propagating waves of spontaneous activity arising from discrete pacemakers in the neonatal mouse cerebral cortex.Lischalk JW, Easton CR, Moody WJ.Dev Neurobiol. 2009 Jun;69(7):407-14.

Scientific focus :

B.S. Molecular Biology, Yale University
Ph.D. Neurobiology, Stanford University
Postdoctoral Work UCLA; University of Bristol
Professor, Department of Biology
Director, Undergraduate Program in Neurobiology

Pascal Branchereau,de l'INCIA